{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:36:44Z","timestamp":1785317804392,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Theranica Ltd."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of treatment onset-time on the effectiveness of remote electrical neuromodulation (REN) for acute treatment of migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A real-world evidence study on migraine patients who treated with REN . REN treatments initiated within one hour of migraine attack onset (headache or aura) were classified as \u201cearly\u201d; those initiated after one hour were classified as \u201clate\u201d. Treatments with baseline and two-hour reports were termed \u201cevaluable\u201d and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 55,261 patients (37.9\u2009\u00b1\u200918.5 years, 83.4% female) who conducted 586,981 treatments, 56.5% were administered early. Effectiveness was calculated from \u201cevaluable\u201d treatments, varying between 6413 and 35,581 treatments depending on the outcome. Early treatments yielded higher responder-rates than late (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, significant following Bonferroni correction for multiple comparisons) for pain relief (65.1% vs. 46.6%; \u0394\u2009=\u200918.5%), pain freedom (28.8% vs. 14.5%; \u0394\u2009=\u200914.3%), functional disability relief (58.1% vs. 49.3%; \u0394\u2009=\u20098.8%), functional disability freedom (35.4% vs. 20.9%; \u0394\u2009=\u200914.5%), and freedom from photophobia (26.9% vs. 19.0%; \u0394\u2009=\u20097.9%), phonophobia (34.0% vs. 25.9%; \u0394\u2009=\u20098.1%) and nausea\/vomiting (51.5% vs. 38.7%; \u0394\u2009=\u200912.8%). Similarly, patients consistently treating early with REN (in 50% or more of their treatments) experienced higher efficacy (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similar effects were seen in youths.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early acute treatment with REN enhanced patient outcomes by up to two-fold compared to late treatment onset. Educating providers and patients to \u201ctreat as early as possible\u201d boosts clinical and patient-centered results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251370696","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T03:35:22Z","timestamp":1760067322000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of treatment onset time on acute efficacy in migraine patients treating with remote electrical neuromodulation (REN)"],"prefix":"10.1177","volume":"45","author":[{"given":"Jessica","family":"Ailani","sequence":"first","affiliation":[{"name":"Department of Neurology, Medstar Georgetown University Hospital, Headache Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Tomaschek","sequence":"additional","affiliation":[{"name":"Dent Neurologic Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-6447","authenticated-orcid":false,"given":"Alit","family":"Stark-Inbar","sequence":"additional","affiliation":[{"name":"Theranica, Netanya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Shmuely","sequence":"additional","affiliation":[{"name":"Theranica, Netanya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Ironi","sequence":"additional","affiliation":[{"name":"Theranica, Netanya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-3111","authenticated-orcid":false,"given":"Daniel Noam","family":"Lax","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00763-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00756.x"},{"key":"e_1_3_2_6_2","first-page":"15","article-title":"Early treatment of acute migraine: new evidence of benefits","volume":"29","author":"Valade D","year":"2009","unstructured":"Valade D. Early treatment of acute migraine: new evidence of benefits. Cephalalgia 2009; 29: 15\u201321.","journal-title":"Cephalalgia"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201031"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.93"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/2514183X18823377"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241252666"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001256"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01204-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000126"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13551"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14469"},{"key":"e_1_3_2_17_2","article-title":"Safety and efficacy of remote electrical neuromodulation for the acute treatment of chronic migraine: an open-label study","volume":"6","author":"Grosberg B","year":"2021","unstructured":"Grosberg B, Rabany L, Lin T, et al. Safety and efficacy of remote electrical neuromodulation for the acute treatment of chronic migraine: an open-label study. Pain Rep 2021; 6: e966.","journal-title":"Pain Rep"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14042"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.753736"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cns3.20073"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02697-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01848-4"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251370696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024251370696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251370696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:33Z","timestamp":1777387593000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024251370696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/03331024251370696"],"URL":"https:\/\/doi.org\/10.1177\/03331024251370696","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"03331024251370696"}}