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To determine whether pretreatment of CBD:THC could counteract CGRP-induced light aversion, we utilized the light\/dark assay, which also recorded motility behavior. To investigate whether CBD:THC pretreatment could alleviate CGRP-induced spontaneous pain, we used the automated squint assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings show that pretreatment with 100:1 CBD:THC rescued light aversion caused by centrally administered CGRP in CD1 mice. Additionally, CBD:THC pretreatment rescued the increased resting time in darkness, decreased transitions between light and dark zones, and partially rescued the decreased rearing behavior induced by centrally administered CGRP. Moreover, an open field assay confirmed that centrally administered CGRP did not induce anxiety in a light independent assay. Finally, our findings from the automated squint assay indicate that pretreatment with 100:1 CBD:THC partially rescued centrally administered CGRP-induced spontaneous pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, these results demonstrate that a combination of CBD and THC can alleviate light aversion and pain symptoms induced by a centrally-acting migraine trigger.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251392103","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:14:56Z","timestamp":1762190096000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-9959","authenticated-orcid":false,"given":"Erik","family":"Zorrilla","sequence":"first","affiliation":[{"name":"University of Iowa"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-0777","authenticated-orcid":false,"given":"Thomas L.","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4252-6686","authenticated-orcid":false,"given":"Cassandra L.","family":"Pi\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-5649","authenticated-orcid":false,"given":"Andrew F.","family":"Russo","sequence":"additional","affiliation":[{"name":"University of Iowa"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Department of Neurology, University of Iowa, Iowa City, IA, USA"},{"name":"Center for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs Health Center, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010917"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0845-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32160-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00842-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06260-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823357-3.00008-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00198-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06184-8"},{"key":"e_1_3_3_10_2","first-page":"20210630","article-title":"CGRP Induces migraine-like symptoms in mice during both the active and inactive phases","volume":"22","author":"Wattiez AS","year":"2021","unstructured":"Wattiez AS, Gaul OJ, Kuburas A, et al. 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