{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:35:30Z","timestamp":1793327730576,"version":"4.5.0"},"reference-count":88,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the IHS Research into Headache in Children and Adolescents Seed"},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Current Research"],"award-info":[{"award-number":["Current Research"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine accounts for most primary headaches in children and adolescents and is related to cortical and connectivity changes. However, the underlying mechanisms remain unclear. Morphometric similarity mapping has not yet been applied to children and adolescents with migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-three patients (6\u201317 years) with migraine without aura and 81 age- and sex-matched controls were retrospectively included. High-resolution 3D T1-weighted and diffusion-weighted magnetic resonance imaging scans were processed to extract cortical morphometric parameters and compute morphometric similarity networks (MSN). Global and regional MSN differences were assessed between patients and controls, and across subgroups defined by sex, attack frequency and migraine-associated symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients showed significant MSN alterations, particularly in temporal and cingulate regions. Sex emerged as the strongest factor influencing MSN architecture, with additional modulations linked to attack frequency and clinical symptoms. Affected pathways encompassed the executive control, nociceptive and default mode networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Migraine in children and adolescents is associated with widespread MSN abnormalities, likely reflecting cortical reorganization mechanisms. Male and female patients appear to engage distinct neural \u201corchestras\u201d, each emphasizing different network sections (sensory\u2013affective in males and cognitive\u2013attentive in females) to produce a shared clinical experience. These findings highlight sex as a key determinant of migraine neurobiology in developmental age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024261416494","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:36:38Z","timestamp":1775486198000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex-specific orchestration of morphometric similarity networks in children and adolescents with migraine"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-9205","authenticated-orcid":false,"given":"Laura","family":"Papetti","sequence":"first","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Guarnera","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"},{"name":"Sant\u2019 Andrea Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-6846","authenticated-orcid":false,"given":"Antonio","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Baldassari","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-8752","authenticated-orcid":false,"given":"Greta","family":"Pirani","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Sforza","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7784","authenticated-orcid":false,"given":"Gabriele","family":"Monte","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Ursitti","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Dellepiane","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Carboni","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Camilla","family":"Rossi-Espagnet","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"},{"name":"Sant\u2019 Andrea Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Moltoni","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"},{"name":"Sant\u2019 Andrea Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gandolfo","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-103X","authenticated-orcid":false,"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children's Hospital, IRCCS"},{"name":"Aalborg University"},{"name":"Tor Vergata University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0783-5"},{"key":"e_1_3_2_3_2","article-title":"Hierarchical alteration of brain structural and functional networks in female migraine sufferers","volume":"7","author":"Liu J","year":"2012","unstructured":"Liu J, Zhao L, Li G, et al. 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