{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:01:03Z","timestamp":1780556463161,"version":"3.54.1"},"reference-count":84,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NYU Langone Health Interdisciplinary Pain Research Program (IPRP\u2019s) pilot project award"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n Background<\/jats:title>\n Few studies have examined which patients with migraine might be responders for mind-body interventions. Thus, we examined whether certain baseline mindfulness traits and interest in physical exercise might predict response to treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This is a planned exploratory analysis of a phase 2 randomized controlled study (\n N<\/jats:italic>\n \u2009\u2009=\u2009\u200950; 25 per arm) comparing a 6-week physical therapist (PT)-delivered biofeedback-assisted relaxation (BAR) program vs. an Enhanced Usual Care (EUC) migraine self-management program (diary tracking and emailed migraine-related educational materials). We conducted moderation analyses to determine whether the Multidimensional Assessment of Interoceptive Awareness (MAIA), Difficulties in Emotion Regulation Scale (DERS) and Physical Activity Enjoyment Scale (PACES) at baseline influenced the effect of BAR on migraine-related outcomes (Migraine-Specific Quality of Life Role Function Restrictive (MSQv2.1-RFR) and Migraine-Related Disability (MIDAS)) at 6 months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the\n n<\/jats:italic>\n \u2009=\u200940 participants (BAR\u2009=\u200919; EUC\u2009=\u200921), the majority were female (95%), non-Hispanic (77.5%) and white (67.5%). Mean (SD) age was 45.6 (11.2) years. For the MAIA Not-Worrying subscale, BAR produced the greatest improvement in 6-month MSQv2.1-RFR scores among participants with low baseline Not-Worrying scores (those who tended to worry about bodily sensations\/discomfort more) (BAR\u2009=\u200977.1\u2009\u00b1\u20096.6 vs. EUC\u2009=\u200948.9\u2009\u00b1\u20095.0;\n p<\/jats:italic>\n \u2009=\u20090.002,\n g<\/jats:italic>\n \u2009=\u20094.75). The benefit diminished at average levels (\n p<\/jats:italic>\n \u2009=\u20090.060,\n g<\/jats:italic>\n \u2009=\u20092.72) and was absent at high baseline Not-Worrying (\n p<\/jats:italic>\n \u2009=\u20090.528,\n g<\/jats:italic>\n \u2009=\u2009 \u22120.91). For the MAIA Self-Regulation subscale, BAR was most effective among those low in baseline self-regulation (BAR\u2009=\u200971.7\u2009\u00b1\u20095.3 vs. EUC\u2009=\u200944.3\u2009\u00b1\u20097.2;\n p<\/jats:italic>\n \u2009=\u20090.004,\n g<\/jats:italic>\n \u2009=\u20094.27). The DERS total score showed that BAR demonstrated little benefit among participants with better baseline emotion regulation (i.e. lower DERS score;\n p<\/jats:italic>\n \u2009=\u20090.907,\n g<\/jats:italic>\n \u2009=\u20090.17) but was more effective as baseline emotion regulation difficulties increased, showing a moderate benefit at average levels (BAR\u2009=\u200969.2\u2009\u00b1\u20094.2 vs. EUC\u2009=\u200955.8\u2009\u00b1\u20094.0,\n p<\/jats:italic>\n \u2009=\u20090.027,\n g<\/jats:italic>\n \u2009=\u20093.25) and a large, significant difference at high levels (BAR\u2009=\u200970.6\u2009\u00b1\u20096.3 vs. EUC\u2009=\u200944.7\u2009\u00b1\u20095.7;\n p<\/jats:italic>\n \u2009=\u20090.004,\n g<\/jats:italic>\n \u2009=\u20094.22). The PACES total score indicated that BAR benefits were strongest among those with low (BAR\u2009=\u200976.1\u2009\u00b1\u20097.0 vs. EUC\u2009=\u200947.1\u2009\u00b1\u20095.3,\n p<\/jats:italic>\n \u2009=\u20090.002,\n g<\/jats:italic>\n \u2009=\u20094.60) to average (BAR\u2009=\u200971.2\u2009\u00b1\u20094.2 vs. EUC\u2009=\u200958.6\u2009\u00b1\u20094.0,\n p<\/jats:italic>\n \u2009=\u20090.035,\n g<\/jats:italic>\n \u2009=\u20093.07) enjoyment of physical activity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We found subgroups of individuals with migraine who may be better responders to PT-delivered BAR, specifically those who tend to worry more about bodily sensations (lower MAIA Not-Worrying score), those with low self-regulation (lower MAIA Self-Regulation score), those with worse emotion regulation (higher DERS score) and those with lower levels of physical activity enjoyment (lower PACES score) at baseline. This may help us determine who may benefit most from BAR.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n ClinicalTrials.gov Identifier: NCT06077812.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/03331024261441579","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:08:15Z","timestamp":1780304895000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of response to biofeedback-assisted relaxation for migraine: An exploratory analysis"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-6180","authenticated-orcid":false,"given":"Kristin L","family":"Szuhany","sequence":"first","affiliation":[{"name":"New York University Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8401-8365","authenticated-orcid":false,"given":"Julia","family":"Dorf","sequence":"additional","affiliation":[{"name":"NYU Langone Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C","family":"Bostic","sequence":"additional","affiliation":[{"name":"MIST Research & Statistical Consulting, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1489","authenticated-orcid":false,"given":"Kristina M","family":"Fanning","sequence":"additional","affiliation":[{"name":"MIST Research & Statistical Consulting, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-3703","authenticated-orcid":false,"given":"Mia T","family":"Minen","sequence":"additional","affiliation":[{"name":"NYU Langone Health"},{"name":"NYU Langone Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00038-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4871"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282533"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-36490-7_27"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-024-01361-y"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01197-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01839-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419888230"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14430"},{"key":"e_1_3_2_12_2","article-title":"Evidenced-based guidelines for migraine headache: behavioral and physical treatments","author":"Campbell JK","unstructured":"Campbell JK, Penzien DB, Wall EM. 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