{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:08:34Z","timestamp":1777489714458,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[1983,8,1]],"date-time":"1983-08-01T00:00:00Z","timestamp":428544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:p>Endogenous hyperprolactinaemia induced by anterior pituitary transplantation under the kidney capsule has been found to reduce the behavioural responsiveness to electrical footshock and to increase morphine-induced analgesia. The apparent analgesic effect of prolactin has been related to the stimulation of nigro-striatal dopaminergic transmission, as suggested by the increase in striatal dopamine turnover observed in hyperprolactinaemic rats. It seems likely that central opiate system is involved in the behavioural effects of prolactin. Thus, naloxone prevents the effects of hyperprolactinaemia on footshock responsiveness and heroin self-administration is decreased in hyperprolactinaemic rats.<\/jats:p>\n                  <jats:p>Il a \u00e9t\u00e9 remarqu\u00e9 que l'hyperprolactin\u00e9mie caus\u00e9e per la greffe de l'hypophyse ant\u00e9rieure sous la capsule r\u00e9nale r\u00e9duit la r\u00e9ponse comportamentale au footshock \u00e9lectrique et augmente l'analg\u00e9sie produite par la morphine. L'effet analg\u00e9sique apparent de la prolactine a \u00e9t\u00e9 mis en relation avec le stimulus de la transmission dopaminergique nigro-stri\u00e9e, comme il est sugg\u00e9r\u00e9 par l'augmentation du turnover de la dopamine stri\u00e9e chez les rats hyperprolac-tin\u00e9miques. Il est probable que le syst\u00e8me central opioide joue un r\u00f4le dans les effets comportamentaux de la prolactine. Le naloxone est donc \u00e0 m\u00eame de pr\u00e9venir les effets de l'hyperprolactin\u00e9mie sur la r\u00e9ponse au footshock et de r\u00e9duire l'autoadministration de l'h\u00e9roine chez les rats hyperprolactin\u00e9miques.<\/jats:p>\n                  <jats:p>L'iperprolattinemia indotta da trapianto di ipofisi anteriore sotto la capsula renale \u00e8 nota ridurre la risposta comportamentale al footshock elettrico e l'analgesia indotta da morfina. Questo apparente effetto analgesico della prolattina \u00e8 stato messo in rapporto con la stimolazione della trasmissione dopaminergica nigro-striatale, come suggerito dall'incremento del turnover di dopamina striatale osservato in ratti iperprolattinemici. Sembra quindi verosimile che il sistema oppioide centrale sia coinvolto negli effetti comportamentali della prolattina. Il naloxone peraltro \u00e8 in grado di prevenire gli effetti della iperprolattinemia sulla risposta al footshock come di ridurre l'autosomministrazione di eroina nei ratti iperprolattinemici.<\/jats:p>","DOI":"10.1177\/03331024830030s103","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T03:43:56Z","timestamp":1500263036000},"page":"31-34","source":"Crossref","is-referenced-by-count":4,"title":["Role of prolactin-opiate interactions in the central regulation of pain threshold"],"prefix":"10.1177","volume":"3","author":[{"given":"Ferdinando","family":"Nicoletti","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Catania, Catania, Italy and Institute of Pathophysiology, University Medical School, Szeged, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Drago","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Catania, Catania, Italy and Institute of Pathophysiology, University Medical School, Szeged, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Speciale","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Catania, Catania, Italy and Institute of Pathophysiology, University Medical School, Szeged, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Gabor","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Catania, Catania, Italy and Institute of Pathophysiology, University Medical School, Szeged, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Scapagnini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Catania, Catania, Italy and Institute of Pathophysiology, University Medical School, Szeged, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,8,1]]},"reference":[{"key":"bibr1-03331024830030S103","unstructured":"Caccamo G, Continella G, Auditore S, Cavaliere S, Drago F. Amphetamine induced-analgesia is blocked by peripheral administration of haloperidol. Abs. International Joint Meeting of Scandinavian Pharmacological Society & Italian Pharmacological Society, Taormina, 25-28 April, 1983: 97"},{"key":"bibr2-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1969.tb08183.x"},{"key":"bibr3-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572268"},{"key":"bibr4-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)91013-7"},{"key":"bibr5-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1007\/BF01248953"},{"key":"bibr6-03331024830030S103","first-page":"95","volume-title":"Progress in prolactin physiology and pathology.","author":"Fuxe K","year":"1978"},{"key":"bibr7-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(78)90154-9"},{"key":"bibr8-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90007-3"},{"key":"bibr9-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90281-8"},{"key":"bibr10-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(81)90339-7"},{"key":"bibr11-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90688-3"},{"key":"bibr12-03331024830030S103","first-page":"73","volume-title":"Characteristics and functions of opioids.","author":"van Wimersma Greidanus T B","year":"1978"},{"key":"bibr13-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(77)90511-2"},{"key":"bibr14-03331024830030S103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1979.hed1905273.x"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024830030S103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024830030S103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:44:24Z","timestamp":1777387464000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024830030S103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":14,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["10.1177\/03331024830030S103"],"URL":"https:\/\/doi.org\/10.1177\/03331024830030s103","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}