{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:14:33Z","timestamp":1777490073551,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5_suppl","license":[{"start":{"date-parts":[[1986,5,1]],"date-time":"1986-05-01T00:00:00Z","timestamp":515289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>\n                    Alterations in platelet function and other hemorheologic factors have been reported to occur in patients with migraine. The prophylactic treatment of migraine with beta blockers is at present well established, and non-selective as well as \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    -selective beta blockers exert an effect. The aim of this presentation is to summarize how beta blockers, depending on their receptor selectivity, modulate platelet function and hemorheologic factors. We conclude that nonselective beta blockade increases factors, such as platelet aggregability, and decreases fibrinolytic activity compared with \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    -selective blockade with metoprolol. These differences do not reflect on their migraine prophylactic effect and indicate that alterations in platelet function are not a primary cause of migraine: rather, they are epiphenomena.\n                  <\/jats:p>","DOI":"10.1177\/03331024860060s504","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T05:29:48Z","timestamp":1500269388000},"page":"33-40","source":"Crossref","is-referenced-by-count":10,"title":["Beta-Adrenoceptor Blockade, Platelets, and Rheologic Factors"],"prefix":"10.1177","volume":"6","author":[{"given":"K","family":"Winther","sequence":"first","affiliation":[{"name":"Coagulation Laboratory, Department of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, University of Gothenburg, Gothenburg, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"key":"bibr1-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91049-7"},{"key":"bibr2-03331024860060S504","first-page":"29","volume":"2","author":"Anthony M","year":"1969","journal-title":"Res Clin Stud Headache"},{"key":"bibr3-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1976.tb04342.x"},{"key":"bibr4-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024860060S502"},{"key":"bibr5-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1984.tb01928.x"},{"key":"bibr6-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024850050S3165"},{"key":"bibr7-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1038\/194927b0"},{"key":"bibr8-03331024860060S504","unstructured":"Joseph R, Steiner TJ, Schultz LUC, Clifford Rose F. Does the mode of action of beta-blockers in migraine involve alteration of platelet function? Proceedings of the 5th International Migraine Symposium, London 1984."},{"key":"bibr9-03331024860060S504","first-page":"899","volume":"102","author":"Boogaerts MA","year":"1983","journal-title":"J Lab Clin Med"},{"key":"bibr10-03331024860060S504","unstructured":"Ernst E, Roloff CH, Marshall M. Beta-blocker erh\u00f6ht Blutfluidit\u00e4t. Herz + Gef\u00e4sse 1984:470\u20139."},{"key":"bibr11-03331024860060S504","first-page":"495","volume":"1","author":"Paleretti G","year":"1981","journal-title":"Clin Hemorheol"},{"key":"bibr12-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024850050S3164"},{"key":"bibr13-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024850050S338"},{"key":"bibr14-03331024860060S504","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1016\/S0021-9258(17)40389-9","volume":"252","author":"Sinha AK","year":"1977","journal-title":"J Biol Chem"},{"key":"bibr15-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91849-4"},{"issue":"1","key":"bibr16-03331024860060S504","first-page":"551","volume":"5","author":"Van Brummelen P","year":"1983","journal-title":"J Cardiovasc Pharmacol"},{"key":"bibr17-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800650315"},{"key":"bibr18-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1974.tb02323.x"},{"key":"bibr19-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.6.4.557"},{"key":"bibr20-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024850050S305"},{"key":"bibr21-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1177\/03331024850050S303"},{"key":"bibr22-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050200057018"},{"issue":"1","key":"bibr23-03331024860060S504","first-page":"1","volume":"74","author":"Winther K","year":"1985","journal-title":"Thromb Haemost"},{"key":"bibr24-03331024860060S504","author":"Winther K","year":"1986","journal-title":"Thromb Res"},{"issue":"1","key":"bibr25-03331024860060S504","first-page":"1","volume":"54","author":"Kooistra TJ","year":"1985","journal-title":"Thromb Haemost"},{"key":"bibr26-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1984.0402091.x"},{"key":"bibr27-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1984.tb00815.x"},{"key":"bibr28-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1980.h2004006.x"},{"key":"bibr29-03331024860060S504","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90475-5"},{"key":"bibr30-03331024860060S504","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.HYP.6.6_Pt_2.III163","volume":"6","author":"Spence D","year":"1984","journal-title":"Hypertension"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024860060S504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024860060S504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:08Z","timestamp":1777387568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024860060S504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":30,"journal-issue":{"issue":"5_suppl","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1177\/03331024860060S504"],"URL":"https:\/\/doi.org\/10.1177\/03331024860060s504","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}