{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:16:25Z","timestamp":1790061385404,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elbow epicondylar tendinosis is a common problem that usually resolves with nonoperative treatments. When these measures fail, however, patients are interested in an alternative to surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Treatment of chronic severe elbow tendinosis with buffered platelet-rich plasma will reduce pain and increase function in patients considering surgery for their problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Cohort study; Level of evidence, 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred forty patients with elbow epicondylar pain were evaluated in this study. All these patients were initially given a standardized physical therapy protocol and a variety of other nonoperative treatments. Twenty of these patients had significant persistent pain for a mean of 15 months (mean, 82 of 100; range, 60-100 of 100 on a visual analog pain scale), despite these interventions. All patients were considering surgery. This cohort of patients who had failed nonoperative treatment was then given either a single percutaneous injection of platelet-rich plasma (active group, n = 15) or bupivacaine (control group, n = 5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight weeks after the treatment, the platelet-rich plasma patients noted 60% improvement in their visual analog pain scores versus 16% improvement in control patients (P =. 001). Sixty percent (3 of 5) of the control subjects withdrew or sought other treatments after the 8-week period, preventing further direct analysis. Therefore, only the patients treated with platelet-rich plasma were available for continued evaluation. At 6 months, the patients treated with platelet-rich plasma noted 81% improvement in their visual analog pain scores (P =. 0001). At final follow-up (mean, 25.6 months; range, 12-38 months), the platelet-rich plasma patients reported 93% reduction in pain compared with before the treatment (P &lt;. 0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation. Further evaluation of this novel treatment is warranted. Finally, platelet-rich plasma should be considered before surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546506288850","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T05:03:47Z","timestamp":1149051827000},"page":"1774-1778","source":"Crossref","is-referenced-by-count":653,"title":["Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma"],"prefix":"10.1177","volume":"34","author":[{"given":"Allan","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Pavelko","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr1-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200205000-00018"},{"key":"bibr2-0363546506288850","first-page":"37","volume":"17","author":"Barrett S","year":"2004","journal-title":"Podiatr Today"},{"key":"bibr3-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2003.50041"},{"key":"bibr4-0363546506288850","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300003-00014"},{"key":"bibr5-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1177\/014556130308200814"},{"key":"bibr6-0363546506288850","first-page":"39","volume":"18","author":"Hill J","year":"1989","journal-title":"Contemp Orthop"},{"key":"bibr7-0363546506288850","first-page":"1377","volume-title":"49th Annual Meeting of the Orthopedic Research Society","author":"Jensen T"},{"key":"bibr8-0363546506288850","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-199401000-00001"},{"key":"bibr9-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200208000-00015"},{"key":"bibr10-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2002.34004"},{"key":"bibr11-0363546506288850","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200333050-00004"},{"key":"bibr12-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"bibr13-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B6.13909"},{"key":"bibr14-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200110000-00002"},{"key":"bibr15-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1177\/03635465030310020601"},{"key":"bibr16-0363546506288850","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02752"},{"key":"bibr17-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100130504"},{"key":"bibr18-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310004138"},{"key":"bibr19-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.12.1166"},{"key":"bibr20-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505276758"},{"key":"bibr21-0363546506288850","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000195927.81845.46"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546506288850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0363546506288850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546506288850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:40:06Z","timestamp":1777369206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0363546506288850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1177\/0363546506288850"],"URL":"https:\/\/doi.org\/10.1177\/0363546506288850","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}