{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:24:52Z","timestamp":1777685092713,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,1,19]],"date-time":"2008-01-19T00:00:00Z","timestamp":1200700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the natural healing capacity of damaged articular cartilage is poor, joint surface injuries are a prime target for regenerative medicine. Characterized chondrocyte implantation uses an autologous cartilage cell therapy product that has been optimized for its biological potency to form stable cartilage tissue in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether, in symptomatic cartilage defects of the femoral condyle, structural regeneration with characterized chondrocyte implantation is superior to repair with microfracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Randomized controlled trial; Level of evidence, 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Characterized chondrocyte implantation was compared with microfracture in patients with single grade III to IV symptomatic cartilage defects of the femoral condyles in a multicenter trial. Patients aged 18 to 50 years were randomized to characterized chondrocyte implantation (n = 57) or microfracture (n = 61). Structural repair was blindly assessed in biopsy specimens taken at 1 year using (1) computerized histomorphometry and (2) evaluation of overall histological components of structural repair. Clinical outcome was measured using the self administered Knee injury and Osteoarthritis Outcome Score. Adverse events were recorded throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Characterized chondrocyte implantation resulted in better structural repair, as assessed by histomorphometry ( P = .003) and overall histologic evaluation ( P = .012). Aspects of structural repair relating to chondrocyte phenotype and tissue structure were superior with characterized chondrocyte implantation. Clinical outcome as measured by the Knee injury and Osteoarthritis Outcome Score at 12 to 18 months after characterized chondrocyte implantation was comparable with microfracture at this stage. Both treatment groups had a similar mean baseline overall Knee injury and Osteoarthritis Outcome Score (56.30 \u00b1 13.61 and 59.53 \u00b1 14.95 for microfracture and characterized chondrocyte implantation, respectively), which increased in both groups to 70.56 \u00b1 12.39 and 72.63 \u00b1 15.55 at 6 months, 73.26 \u00b1 14.66 and 73.10 \u00b1 16.01 at 12 months, and 74.73 \u00b1 17.01 and 75.04 \u00b1 14.50 at 18 months, respectively. Both techniques were generally well tolerated; the incidence of adverse events after characterized chondrocyte implantation was not markedly increased compared with that for microfracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One year after treatment, characterized chondrocyte implantation was associated with a tissue regenerate that was superior to that after microfracture. Short-term clinical outcome was similar for both treatments. The superior structural outcome may result in improved long-term clinical benefit with characterized chondrocyte implantation. Long-term follow-up is needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546507311095","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T15:28:42Z","timestamp":1200583722000},"page":"235-246","source":"Crossref","is-referenced-by-count":546,"title":["Characterized Chondrocyte Implantation Results in Better Structural Repair when Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus Microfracture"],"prefix":"10.1177","volume":"36","author":[{"given":"Daniel B. F.","family":"Saris","sequence":"first","affiliation":[{"name":"Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands"}]},{"given":"Johan","family":"Vanlauwe","sequence":"additional","affiliation":[{"name":"Department Orthopedics, University Hospitals Leuven, Leuven, Belgium"}]},{"given":"Jan","family":"Victor","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, AZ St Lucas Brugge, Brugge, Belgium"}]},{"given":"Miroslav","family":"Haspl","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia"}]},{"given":"Michael","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Hannover Medical School, Hannover, Germany"}]},{"given":"Yves","family":"Fortems","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, AZ St Jozef, Malle, Belgium"}]},{"given":"Bruno","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, AZ St Jan Brugge, Brugge, Belgium"}]},{"given":"K. Frederik","family":"Almqvist","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Ghent University Hospital, Ghent, Belgium"}]},{"given":"Toon","family":"Claes","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, AZ St Elisabeth, Herentals, Belgium"}]},{"given":"Frank","family":"Handelberg","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Universitair Ziekenhuis Brussel, Brussels, Belgium"}]},{"given":"Koen","family":"Lagae","sequence":"additional","affiliation":[{"name":"SPM Monica, Antwerp, Belgium"}]},{"given":"Jan","family":"van der Bauwhede","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, AZ Groeninge, Kortrijk, Belgium"}]},{"given":"Hilde","family":"Vandenneucker","sequence":"additional","affiliation":[{"name":"Department Orthopedics, University Hospitals Leuven, Leuven, Belgium"}]},{"given":"K. 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