{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:43:13Z","timestamp":1784616193992,"version":"3.55.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T00:00:00Z","timestamp":1229904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of full-thickness talar cartilage defects that have failed previous surgery is problematic without a definitive solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the first US prospective study of autologous chondrocyte implantation of the talus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series; Level of evidence, 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eleven patients (6 women and 5 men; mean age, 33 years) underwent autologous chondrocyte implantation of the talus after previous failed surgical management. There were 9 medial and 2 lateral lesions, with a mean size of 21 \u00d7 13 mm (273 mm2). Five patients underwent autologous chondrocyte implantation of the talus alone; 6 had it with a \u201csandwich procedure.\u201d Ten patients underwent a second-look arthroscopy with screw removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean follow-up was 38 months. Preoperatively, 10 patients rated their ankles as poor and 1 as fair, using the simplified symptomatology evaluation. At latest follow-up, 3 patients were classified as excellent, 6 as good, and 2 as fair. Tegner activity level improved from 1.3 \u00b1 1.0 (mean \u00b1 SE) preoperatively to 4.0 \u00b1 1.6 (P &lt;. 002) postoperatively. The Finsen score (modified Weber score) showed significant improvement in the total score (P &lt;. 001). There was also overall agreement between the Finsen score and the American Orthopaedic Foot and Ankle Society ankle hindfoot score, with significant improvement from 47.4 \u00b1 17.4 preoperatively to 84.3 \u00b1 8.1 postoperatively (P &lt;. 001). At repeat arthroscopy, complete coverage of the defect was seen in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autologous chondrocyte implantation of the talus yields significant functional improvement; however, further investigation is necessary to determine the long-term structural and biomechanical properties of the repair tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546508325670","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:09:42Z","timestamp":1229980182000},"page":"274-284","source":"Crossref","is-referenced-by-count":96,"title":["Autologous Chondrocyte Implantation of the Ankle"],"prefix":"10.1177","volume":"37","author":[{"given":"Ellis Kevin","family":"Nam","sequence":"first","affiliation":[{"name":"Chicago Orthopedic and Sports Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Ferkel","sequence":"additional","affiliation":[{"name":"Southern California Orthopedic Institute, Van Nuys, California"},{"name":"Center for Health Science, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Applegate","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California-San Diego, California"},{"name":"Centers for MRI, Southern California Orthopedic Institute, Van Nuys, California"},{"name":"Pacific Advanced Radiology, Van Nuys, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"bibr1-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2171(01)90025-3"},{"key":"bibr2-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110070202300502"},{"key":"bibr3-0363546508325670","unstructured":"AndersonAFRating scales. In: FuFH, HarnerCD, VinceKG, eds. Knee Surgery. Baltimore, Md: Williams & Wilkins; 1994:275\u2013279."},{"key":"bibr4-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200703"},{"key":"bibr5-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200602000-00008"},{"key":"bibr6-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00132587-200403000-00009"},{"key":"bibr7-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.02.012"},{"key":"bibr8-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195941060-00002"},{"key":"bibr9-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S1048-6666(97)80032-8"},{"key":"bibr10-0363546508325670","first-page":"387","volume":"44","author":"Blom JM","year":"1975","journal-title":"Radiol Clin"},{"key":"bibr11-0363546508325670","first-page":"17","volume":"9","author":"Brittberg M.","year":"2000","journal-title":"Osteologie"},{"key":"bibr12-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"bibr13-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200209000-00004"},{"key":"bibr14-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5919(05)70130-7"},{"key":"bibr15-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196603000-00007"},{"key":"bibr16-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062010-00014"},{"key":"bibr17-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/230949900301100104"},{"key":"bibr18-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P"},{"key":"bibr19-0363546508325670","volume-title":"Arthroscopic Surgery: The Foot and Ankle","author":"Ferkel RD","year":"1996"},{"key":"bibr20-0363546508325670","unstructured":"FerkelRDArthroscopy of the ankle and foot. In: MannRA, CoughlinM, eds. Surgery of the Foot and Ankle. 6th ed. St Louis, Mo: Mosby; 1993:1277\u20131310."},{"key":"bibr21-0363546508325670","unstructured":"FerkelRD, ChengJ.Ankle and subtalar arthroscopy. In: KelikianA, ed. Operative Treatment of the Foot and Ankle. Stanford, Conn: Appleton and Lange; 1999:321\u2013350."},{"key":"bibr22-0363546508325670","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00003086-198903000-00027","volume":"240","author":"Ferkel RD","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"bibr23-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199308000-00016"},{"key":"bibr24-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508316773"},{"key":"bibr25-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971010-00005"},{"key":"bibr26-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1998.tb02103.x"},{"key":"bibr27-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110078500500403"},{"key":"bibr28-0363546508325670","first-page":"197","volume":"213","author":"Gebstein R.","year":"1986","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"bibr29-0363546508325670","first-page":"28","volume":"87","author":"Giannini S.","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"bibr30-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200612"},{"key":"bibr31-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.02.010"},{"key":"bibr32-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-7515(02)00023-2"},{"key":"bibr33-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.05.016"},{"key":"bibr34-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00002142-199812000-00006"},{"key":"bibr35-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20482"},{"key":"bibr36-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505281918"},{"key":"bibr37-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110079701801005"},{"key":"bibr38-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200704"},{"key":"bibr39-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200302000-00001"},{"key":"bibr40-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110079401500701"},{"key":"bibr41-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200710000-00002"},{"key":"bibr42-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200403000-00001"},{"key":"bibr43-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200202000-00021"},{"key":"bibr44-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B2.17009"},{"key":"bibr45-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199909000-00004"},{"key":"bibr46-0363546508325670","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20061001-17"},{"key":"bibr47-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20135"},{"key":"bibr48-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2003.09.039"},{"key":"bibr49-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000165737.87628.5b"},{"key":"bibr50-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S1048-6666(97)80036-5"},{"key":"bibr51-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199908000-00020"},{"key":"bibr52-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/0749-8063(91)90101-3"},{"key":"bibr53-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199501000-00009"},{"key":"bibr54-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/03635465020300011601"},{"key":"bibr55-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-7515(03)00045-7"},{"key":"bibr56-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200005000-00020"},{"key":"bibr57-0363546508325670","first-page":"618","volume":"41","author":"Pridie KH","year":"1959","journal-title":"J Bone Joint Surg Br"},{"key":"bibr58-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198668060-00007"},{"key":"bibr59-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2004.11.002"},{"key":"bibr60-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062080-00002"},{"key":"bibr61-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199603000-00018"},{"key":"bibr62-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B3.0840364"},{"key":"bibr63-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B5.17306"},{"key":"bibr64-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200504"},{"key":"bibr65-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B2.15376"},{"key":"bibr66-0363546508325670","doi-asserted-by":"publisher","DOI":"10.1053\/otsm.2000.6577"},{"key":"bibr67-0363546508325670","first-page":"503","volume":"88","author":"Wood JJ","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"bibr68-0363546508325670","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870070-00009"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546508325670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0363546508325670","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546508325670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:39:56Z","timestamp":1777369196000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0363546508325670"}},"subtitle":["A 2- to 5-Year Follow-Up"],"short-title":[],"issued":{"date-parts":[[2008,12,22]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/0363546508325670"],"URL":"https:\/\/doi.org\/10.1177\/0363546508325670","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,22]]}}}