{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:07:16Z","timestamp":1787638036772,"version":"build-2736575974"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T00:00:00Z","timestamp":1295568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Background: The availability remains limited of midterm clinical and radiologic results into matrix-induced autologous chondrocyte implantation (MACI). Outcomes are required to validate the efficacy of MACI as a suitable surgical treatment option for articular cartilage defects in the knee.<\/jats:p>\n                  <jats:p>Hypothesis: A significant improvement in clinical and magnetic resonance imaging\u2013based (MRI-based) outcomes after MACI will exist throughout the postoperative timeline to 5 years after surgery. Furthermore, patient demographics, cartilage defect parameters, and injury\/surgery history will be associated with patient and graft outcome, whereas a significant correlation will exist between clinical and MRI-based outcomes at 5 years after surgery.<\/jats:p>\n                  <jats:p>Study Design: Case series; Level of evidence, 4.<\/jats:p>\n                  <jats:p>Methods: A prospective evaluation was undertaken to assess clinical and MRI-based outcomes to 5 years in 41 patients (53 grafts) after MACI to the knee. After MACI surgery and a 12-week structured rehabilitation program, patients underwent clinical assessments (Knee injury and Osteoarthritis Outcome Score, SF-36, 6-minute walk test, knee range of motion) and MRI assessments at 3, 12, and 24 months, as well as 5 years after surgery. The MRI evaluation assessed 8 previously defined pertinent parameters of graft repair, as well as a combined MRI composite score.<\/jats:p>\n                  <jats:p>Results: A significant improvement ( P &lt; .05) was demonstrated for all Knee injury and Osteoarthritis Outcome Score and SF-36 subscales over the postoperative timeline, as well as the 6-minute walk test and active knee extension. A significant improvement ( P &lt; .0001) was observed for the MRI composite score, as well as several individual graft scoring parameters. At 5 years after surgery, 67% of MACI grafts demonstrated complete infill, whereas 89% demonstrated good to excellent filling of the chondral defect. Patient demographics, cartilage defect parameters, and injury\/surgery history demonstrated no significant pertinent correlations with clinical or MRI-based outcomes at 5 years, and no significant correlations existed between clinical and MRI-based outcome measures. At 5 years after surgery, 98% of patients were satisfied with the ability of MACI surgery to relieve knee pain; 86%, with improvement in their ability to perform normal daily tasks; and 73%, with their ability to participate in sport 5 years after MACI.<\/jats:p>\n                  <jats:p>Conclusion: These results suggest that MACI provides a suitable midterm treatment option for articular cartilage defects in the knee. Long-term follow-up is essential to confirm whether the repair tissue has the durability required to maintain long-term patient quality of life.<\/jats:p>","DOI":"10.1177\/0363546510390476","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T00:25:04Z","timestamp":1295655904000},"page":"753-763","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":135,"title":["Clinical and Magnetic Resonance Imaging\u2013Based Outcomes to 5 Years After Matrix-Induced Autologous Chondrocyte Implantation to Address Articular Cartilage Defects in the Knee"],"prefix":"10.1177","volume":"39","author":[{"given":"Jay R.","family":"Ebert","sequence":"first","affiliation":[{"name":"School of Sport Science, Exercise and Health, University of Western Australia, Crawley, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Robertson","sequence":"additional","affiliation":[{"name":"School of Surgery (Orthopaedics), University of Western Australia, Crawley, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"School of Sport Science, Exercise and Health, University of Western Australia, Crawley, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fallon","sequence":"additional","affiliation":[{"name":"Perth Radiological Clinic, Subiaco, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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