{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:52:34Z","timestamp":1782539554535,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Background: Rotator cuff reconstructions may be improved by adding growth factors, cells, or other biologic factors into the repair zone. This usually requires a biological carrier (scaffold) to be integrated into the construct and placed in the area of tendon-to-bone healing. This needs to be done without affecting the constructs mechanics.<\/jats:p>\n                  <jats:p>Hypothesis\/Purpose: The hypothesis was that scaffold placement, as an interposition, has no adverse effects on biomechanical properties of double-row rotator cuff repair. The purpose of this study was to examine the effect of scaffold interposition on the initial strength of rotator cuff repairs.<\/jats:p>\n                  <jats:p>Study Design: Controlled laboratory study.<\/jats:p>\n                  <jats:p>Methods: Twenty-five fresh-frozen shoulders (mean age: 65.5 \u00b1 8.9 years) were randomly assigned to 5 groups. Groups were chosen to represent a broad spectrum of commonly used scaffold types: (1) double-row repair without augmentation, (2) double-row repair with interposition of a fibrin clot (Viscogel), (3) double-row repair with interposition of a collagen scaffold (Mucograft) between tendon and bone, (4) double-row repair with interposition of human dermis patch (ArthroFlex) between tendon and bone, and (5) double-row repair with human dermis patch (ArthroFlex) placed on top of the repair. Cyclic loading to measure displacement was performed to 3000 cycles at 1 Hz with an applied 10- to 100-N load. The ultimate load to failure was determined at a rate of 31 mm\/min.<\/jats:p>\n                  <jats:p>Results: There were no significant differences in mean displacement under cyclic loading, slope, or energy absorbed to failure between all groups ( P = .128, P = .981, P = .105). Ultimate load to failure of repairs that used the collagen patch as an interposition (573.3 \u00b1 75.6 N) and a dermis patch on top of the reconstruction (575.8 \u00b1 22.6 N) was higher compared with the repair without a scaffold (348.9 \u00b1 98.8 N; P = .018 and P = .025). No significant differences were found for repairs with the fibrin clot as an interposition (426.9 \u00b1 103.6 N) and the decellularized dermis patch as an interposition (469.9 \u00b1 148.6 N; P = .73 and P = .35).<\/jats:p>\n                  <jats:p>Conclusion: Scaffold augmentation did not adversely affect the zero time strength of the tested standard double-row rotator cuff repairs. An increased ultimate load to failure was observed for 2 of the augmentation methods (collagen patch as an interposition and decellularized dermis patch on top of the reconstruction) compared with the nonaugmented repairs.<\/jats:p>\n                  <jats:p>Clinical Relevance: Scaffolds intended for application of growth factors or cellular components in a repair situation did not adversely jeopardize the stability of the operative construct.<\/jats:p>","DOI":"10.1177\/0363546512437835","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:35:15Z","timestamp":1330475715000},"page":"1148-1154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Stability of Double-Row Rotator Cuff Repair Is Not Adversely Affected by Scaffold Interposition Between Tendon and Bone"],"prefix":"10.1177","volume":"40","author":[{"given":"Knut","family":"Beitzel","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"},{"name":"Department of Orthopedic Sports Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Chowaniec","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Cote","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elifho","family":"Obopilwe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas B.","family":"Imhoff","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Sports Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Arciero","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustus D.","family":"Mazzocca","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, 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