{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:45Z","timestamp":1791229605285,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Background: It has been recently reported that human anterior cruciate ligament (ACL) ruptured tissue contains abundant vascular stem cells that contribute to tendon-bone healing in an immunodeficient rat model of ACL reconstruction.<\/jats:p>\n                  <jats:p>Hypothesis: Autologous ruptured ACL tissue has an effect on the maturation of bone-tendon integration in anterior cruciate ligament reconstruction.<\/jats:p>\n                  <jats:p>Study Design: Controlled laboratory study.<\/jats:p>\n                  <jats:p>Methods: Twenty healthy adult beagle dogs underwent bilateral ACL reconstruction using the ipsilateral flexor digitorum superficialis tendon and were divided into 2 groups: right knee (a tissue-treated group) and left knee (a control group). The tissue-treated group received autologous ruptured ACL tissue, which was obtained 2 days after resection and sutured to the tibial side of the graft. Histological, radiographic, and biomechanical assessments were performed. In addition, immunohistochemical staining was performed to assess angiogenesis and osteogenesis.<\/jats:p>\n                  <jats:p>\n                    Results: Histological assessment and staining for osteoblasts and endothelial cells at week 2 demonstrated early healing, inducing endochondral ossification-like integration with enhanced angiogenesis and osteogenesis in the tissue-treated group\u2019s grafts. Computed tomography at week 4 showed a significantly smaller tibial bone tunnel in the tissue-treated group (tissue, 19.0 \u00b1 4.4 mm\n                    <jats:sup>2<\/jats:sup>\n                    ; control, 42.6 \u00b1 4.7 mm\n                    <jats:sup>2<\/jats:sup>\n                    ; P = .009, n = 5). Furthermore, biomechanical testing of force during loading to ultimate failure at week 4 demonstrated a significantly higher strength in the tissue-treated group (tissue, 66.4 \u00b1 10.1 N; control, 30.5 \u00b1 10.3 N; P = .009, n = 5).\n                  <\/jats:p>\n                  <jats:p>Conclusion: In the present study, the authors elucidated that transplantation of ACL-ruptured tissue, which was sutured to the tibial side of the graft, contributed to early tendon-bone healing in a canine model of ACL reconstruction.<\/jats:p>\n                  <jats:p>Clinical Relevance: Anterior cruciate ligament ruptured tissue has a therapeutic potential in promoting an appropriate environment for tendon-to-bone healing in bone tunnels of ACL reconstruction.<\/jats:p>","DOI":"10.1177\/0363546512439026","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T00:27:11Z","timestamp":1331944031000},"page":"1296-1302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":79,"title":["Acceleration of Tendon-Bone Healing of Anterior Cruciate Ligament Graft Using Autologous Ruptured Tissue"],"prefix":"10.1177","volume":"40","author":[{"given":"Tomoyuki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumasa","family":"Tei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Mifune","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kurosaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, 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