{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:23:52Z","timestamp":1790403832934,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:00:00Z","timestamp":1410220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>It is unclear whether matrix-associated autologous chondrocyte transplantation (MACT) results in objective and subjective clinical improvements at 10 years after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Matrix-associated autologous chondrocyte transplantation will result in clinical and radiological improvements in patients with symptomatic, traumatic chondral defects of the knee joint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Case series; Level of evidence, 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 16 patients with chondral defects of the knee were treated with MACT between November 2000 and April 2002 and evaluated for up to 10 years after the intervention. The International Knee Documentation Committee (IKDC) form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner activity score, Brittberg score, Noyes sports activity rating scale, and visual analog scale (VAS) for pain as well as 3-T magnetic resonance imaging (MRI) using the magnetic resonance observation of cartilage repair tissue (MOCART) score and functional evaluation by the limb symmetry index (LSI) formed the basis of this study. The Friedman test and the Wilcoxon signed-rank test were performed for a comparison between all time points and 2 separate time points, respectively. If significant differences were revealed, a Bonferroni adjustment to the \u03b1 level was applied so that P values &lt;.007 (&lt;.05\/7) were regarded as significant in the paired comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Significant improvements ( P &lt; .05) from baseline to 120 months postoperatively were observed for the IKDC score (mean, 44.1 \u00b1 26.9 to 59.0 \u00b1 27.4), Noyes sports activity rating score (mean, 37.7 \u00b1 30.1 to 62.1 \u00b1 31.3), and KOOS Quality of Life and Pain subscores, whereas no statistically significant improvement was detected for the Brittberg score, Tegner activity score, or VAS score. After 5 years, a slight downward tendency of all clinical scores was evident. After 10 years, the mean MOCART score was 70.4 \u00b1 16.1. Complete filling of the defect was observed in 73.9% of cases, and osteophytes were present in 78.3%. In 65.2% of the cases, a subchondral bone edema &lt;1 cm was visible, whereas in 21.7% of the cases, a subchondral bone edema &gt;1 cm was seen. The mean LSI for the single-legged hop test was 95.6% \u00b1 16.2% and for the triple hop test for distance was 91.3% \u00b1 12.2%. The mean VAS score for self-perceived stability was 60.2 \u00b1 3.5 (range, 0-9.5) for the injured and 60.7 \u00b1 3.8 (range, 0-10) for the uninjured leg. No adhesions or effusions were seen regarding the clinical and radiological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The significantly improved results on 3 outcome measures after 10 years suggest that MACT represents a suitable option in the treatment of local cartilage defects in the knee.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546514548160","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T22:48:53Z","timestamp":1410302933000},"page":"2680-2688","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":95,"title":["Clinical and Radiological Long-term Outcomes After Matrix-Induced Autologous Chondrocyte Transplantation"],"prefix":"10.1177","volume":"42","author":[{"given":"Silke","family":"Aldrian","sequence":"first","affiliation":[{"name":"Department of Trauma Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Zak","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wondrasch","sequence":"additional","affiliation":[{"name":"Department of Health & Social Sciences, St P\u00f6lten University of Applied Sciences, St P\u00f6lten, Austria"},{"name":"Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Medical University of Vienna, Vienna, 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