{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:03:28Z","timestamp":1793037808120,"version":"4.5.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anterior cruciate ligament (ACL) injury predisposes individuals to early-onset knee joint osteoarthritis (OA). Abnormal joint loading is apparent after ACL injury and reconstruction. The relationship between altered joint biomechanics and the development of knee OA is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Altered knee joint kinetics and medial compartment contact forces initially after injury and reconstruction are associated with radiographic knee OA 5 years after reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Case-control study; Level of evidence, 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Individuals with acute, unilateral ACL injury completed gait analysis before (baseline) and after (posttraining) preoperative rehabilitation and at 6 months, 1 year, and 2 years after reconstruction. Surface electromyographic and knee biomechanical data served as inputs to an electromyographically driven musculoskeletal model to estimate knee joint contact forces. Patients completed radiographic testing 5 years after reconstruction. Differences in knee joint kinetics and contact forces were compared between patients with and those without radiographic knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with OA walked with greater frontal plane interlimb differences than those without OA (nonOA) at baseline (peak knee adduction moment difference: 0.00 \u00b1 0.08 N\u00b7m\/kg\u00b7m [nonOA] vs \u22120.15 \u00b1 0.09 N\u00b7m\/kg\u00b7m [OA], P = .014; peak knee adduction moment impulse difference: \u22120.001 \u00b1 0.032 N\u00b7m\u00b7s\/kg\u00b7m [nonOA] vs \u22120.048 \u00b1 0.031 N\u00b7m\u00b7s\/kg\u00b7m [OA], P = .042). The involved limb knee adduction moment impulse of the group with osteoarthritis was also lower than that of the group without osteoarthritis at baseline (0.087 \u00b1 0.023 N\u00b7m\u00b7s\/kg\u00b7m [nonOA] vs 0.049 \u00b1 0.018 N\u00b7m\u00b7s\/kg\u00b7m [OA], P = .023). Significant group differences were absent at posttraining but reemerged 6 months after reconstruction (peak knee adduction moment difference: 0.02 \u00b1 0.04 N\u00b7m\/kg\u00b7m [nonOA] vs \u22120.06 \u00b1 0.11 N\u00b7m\/kg\u00b7m [OA], P = .043). In addition, the OA group walked with lower peak medial compartment contact forces of the involved limb than did the group without OA at 6 months (2.89 \u00b1 0.52 body weight [nonOA] vs 2.10 \u00b1 0.69 body weight [OA], P = .036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients who had radiographic knee OA 5 years after ACL reconstruction walked with lower knee adduction moments and medial compartment joint contact forces than did those patients without OA early after injury and reconstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546515608475","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T23:19:25Z","timestamp":1445555965000},"page":"143-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":282,"title":["Decreased Knee Joint Loading Associated With Early Knee Osteoarthritis After Anterior Cruciate Ligament Injury"],"prefix":"10.1177","volume":"44","author":[{"given":"Elizabeth","family":"Wellsandt","sequence":"first","affiliation":[{"name":"University of Delaware, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Gardinier","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Manal","sequence":"additional","affiliation":[{"name":"University of Delaware, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Axe","sequence":"additional","affiliation":[{"name":"University of Delaware, Newark, Delaware, USA"},{"name":"First State Orthopaedics, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"University of Delaware, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Snyder-Mackler","sequence":"additional","affiliation":[{"name":"University of Delaware, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"bibr1-0363546515608475","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2012.3871"},{"key":"bibr2-0363546515608475","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01408"},{"key":"bibr3-0363546515608475","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514526139"},{"key":"bibr4-0363546515608475","doi-asserted-by":"publisher","DOI":"10.1123\/jab.20.4.367"},{"key":"bibr5-0363546515608475","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.052522"},{"key":"bibr6-0363546515608475","unstructured":"Cohen J. 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