{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:35:42Z","timestamp":1788053742938,"version":"build-2784847793"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Medial femoral condyle (MFC) chondral defects cause knee pain. Clinical studies have shown worse functional outcomes and cartilage defect fill rates after microfracture in obese patients (BMI \u226530) and for defects with size \u22652 cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine the effect of obesity, defect size, and cartilage thickness on the force sustained at the base of full-thickness MFC cartilage defects during weightbearing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eight human cadaveric knees were loaded in 15\u00b0 of flexion. A sensor measured force across the medial compartment. The area at the base of the defect protected from load, termed the \u201carea of containment,\u201d was quantified, and loads simulating weightbearing for BMIs of 20, 30, and 40 were applied. A full-thickness cartilage defect was created on the MFC. Cycles of loads were applied for defect sizes with diameters of 6, 8, 10, 12, 14, 16, 18, and 20 mm. A second sensor recorded force at the base of the defect for defects with diameters of 14, 16, 18, and 20 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Loads simulating BMI \u226530 led to a decrease in the area of containment for all defects \u226514 mm in diameter ( P \u2264 .038). Base of defect force increased for defects \u226516 mm in diameter (area, \u22652 cm\n                      <jats:sup>2<\/jats:sup>\n                      ) between loaded and unloaded states ( P \u2264 .042) and for loads simulating BMI \u226530 ( P \u2264 .045). Cartilage rim thickness &lt;2 mm showed higher base of defect force than did thickness \u22652 mm, for all BMI groups ( P \u2264 .025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Increased force at the base of MFC cartilage defects was observed for weightbearing loads simulating BMI \u226530, for defect size \u22652 cm\n                      <jats:sup>2<\/jats:sup>\n                      , and for rim thickness &lt;2 mm. This may lead to a biomechanically unfavorable environment after microfracture in these patient subsets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>\n                      These biomechanical findings corroborate clinical studies that have noted worse outcomes after microfracture in patients with BMI \u226530 and cartilage defects of size \u22652 cm\n                      <jats:sup>2<\/jats:sup>\n                      . Further clinical studies are needed to compare microfracture with other cartilage restoration procedures in these patient subsets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546515613517","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T23:34:34Z","timestamp":1449790474000},"page":"409-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Medial Femoral Condyle Cartilage Defect Biomechanics"],"prefix":"10.1177","volume":"44","author":[{"given":"Kyle W.","family":"Lacy","sequence":"first","affiliation":[{"name":"DMC Sports Medicine, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Cracchiolo","sequence":"additional","affiliation":[{"name":"DMC Sports Medicine, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Yu","sequence":"additional","affiliation":[{"name":"DMC Sports Medicine, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Goitz","sequence":"additional","affiliation":[{"name":"DMC Sports Medicine, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"bibr1-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.09.006"},{"key":"bibr2-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.01.015"},{"key":"bibr3-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000145990.58146.3d"},{"key":"bibr4-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090412"},{"key":"bibr5-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.12.002"},{"key":"bibr6-0363546515613517","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197201000-00033"},{"key":"bibr7-0363546515613517","unstructured":"FlexiForce User Manual. http:\/\/www.tekscan.com\/support\/faqs\/flexiforce-user-manual. 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