{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:33:11Z","timestamp":1785177191970,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The treatment of symptomatic cartilage defects of the patella is particularly challenging, and no gold standard is currently available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the clinical results of a biphasic cell-free collagen-hydroxyapatite scaffold and to evaluate osteochondral tissue regeneration with magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Case series; Level of evidence, 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-four patients (18 men and 16 women; mean \u00b1 SD: age, 30.0 \u00b1 10 years) were treated by scaffold implantation for knee chondral or osteochondral lesions of the patella (area, 2.1 \u00b1 1 cm\n                      <jats:sup>2<\/jats:sup>\n                      ). The clinical evaluation was performed prospectively at 12 and 24 months via the IKDC (International Knee Documentation Committee; objective and subjective) and Tegner scores. MRI evaluation was performed at both follow-ups in 18 lesions through the MOCART score (magnetic resonance observation of cartilage repair tissue) and specific subchondral bone parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A statistically significant improvement in all the scores was observed at 12- and 24-month follow-up as compared with the basal evaluation. The IKDC subjective score improved from 39.5 \u00b1 14.5 to 61.9 \u00b1 14.5 at 12 months ( P &gt; .0005) with a further increase to 67.6 \u00b1 17.4 at 24 months of follow-up (12-24 months, P = .020). The MRI evaluation showed a stable value of the MOCART score between 12 and 24 months, with a complete filling of the cartilage in 87.0% of the lesions, complete integration of the graft in 95.7%, and intact repair tissue surface in 69.6% at final follow-up. The presence of osteophytes or more extensive bony overgrowth was documented in 47.8% of the patients of this series, but no correlation was found between MRI findings and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The implantation of a cell-free collagen-hydroxyapatite osteochondral scaffold provided a clinical improvement at short-term follow-up for the treatment of patellar cartilage defects. Women had lower outcomes, and the need for realignment procedures led to a slower recovery. MRI evaluation showed some abnormal findings with the presence of bone overgrowth, but no correlation has been found with the clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546517694159","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T16:57:19Z","timestamp":1488819439000},"page":"1581-1588","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["One-Step Treatment for Patellar Cartilage Defects With a Cell-Free Osteochondral Scaffold: A Prospective Clinical and MRI Evaluation"],"prefix":"10.1177","volume":"45","author":[{"given":"Francesco","family":"Perdisa","sequence":"first","affiliation":[{"name":"I Orthopaedic and Traumatologic Clinic\u2013University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Filardo","sequence":"additional","affiliation":[{"name":"Nano-biotechnology Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sessa","sequence":"additional","affiliation":[{"name":"I Orthopaedic and Traumatologic Clinic\u2013University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Busacca","sequence":"additional","affiliation":[{"name":"Radiology Department, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Zaffagnini","sequence":"additional","affiliation":[{"name":"Sicily Department, Rizzoli Orthopaedic Institute, Bagheria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Marcacci","sequence":"additional","affiliation":[{"name":"I Orthopaedic and Traumatologic Clinic\u2013University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Kon","sequence":"additional","affiliation":[{"name":"I Orthopaedic and Traumatologic Clinic\u2013University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy"},{"name":"Nano-biotechnology Laboratory, Rizzoli Orthopaedic Institute, Bologna, 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