{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:55:19Z","timestamp":1790726119366,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["No. 81730068, No. 81472072, No. 81171699"],"award-info":[{"award-number":["No. 81730068, No. 81472072, No. 81171699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Fund Project for Young Teachers of Wuhan Sports University","award":["No. 2017Z02"],"award-info":[{"award-number":["No. 2017Z02"]}]},{"name":"Science and Technology Commission of Hunan Province of China","award":["No. 2013GK2002"],"award-info":[{"award-number":["No. 2013GK2002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tendon-bone interface (TBI) injuries are common in sports activities. Owing to the limited regenerative ability of the TBI, its functional healing remains a difficulty in clinical practice. Icariin (ICA) provides strong stimulation for osteogenesis. Platelet-rich plasma (PRP) can be used as a carrier for bioactive molecules, although its ability to provide sustained release for such molecules needs improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Freeze-dried PRP (FD-PRP) as a carrier for ICA can provide sustained release of ICA into the tendon-bone (T-B) healing site, thus accelerating T-B healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 84 New Zealand rabbits with partial patellectomy in the hindlimb were randomly allocated into 3 different treatments: ICA incorporated with FD-PRP (ICA\/FD-PRP), FD-PRP alone (FD-PRP), or saline control (CTL). The rabbit patella\u2013patellar tendon (PP) interfaces were postoperatively harvested at postoperative week 8 or 16 for gross, radiological, histological, and mechanical evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our results showed that FD-PRP can act as a carrier for sustained release of ICA into the T-B healing site. Macroscopically, no signs of infection or osteoarthritis were shown in the regenerated PP interfaces, and the area of cartilaginous metaplasia in the FD-PRP and ICA\/FD-PRP groups at postoperative week 16 was significantly larger than that of the CTL group ( P &lt; .05 for all). Radiologically, micro\u2013computed tomography showed that new bone which formed at the healing site in the ICA\/FD-PRP group was significantly increased, remodeled, and mineralized in comparison with the CTL group ( P &lt; .05 for all). Histologically, the ICA\/FD-PRP group exhibited a significant native PP interface, as shown by the enlargement and remodeling of new bone, well-organized collagen fibers, and robust production of proteoglycans in the regenerated fibrocartilage. The mechanical strength of the regenerated PP interface was significantly improved in the ICA\/FD-PRP group. Significantly higher failure load and stiffness were shown in the ICA\/FD-PRP group compared with the CTL and FD-PRP groups, respectively ( P &lt; .05 for all).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FD-PRP is a suitable sustained-release carrier for ICA, and ICA\/FD-PRP can provide sustained release of ICA into the T-B healing site, thus effectively accelerating T-B healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>Findings of this study demonstrate the feasibility of using FD-PRP as a carrier for ICA to improve T-B healing and provide a foundation for future clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0363546519849657","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T12:31:27Z","timestamp":1559305887000},"page":"1964-1974","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Autologous Freeze-Dried, Platelet-Rich Plasma Carrying Icariin Enhances Bone-Tendon Healing in a Rabbit Model"],"prefix":"10.1177","volume":"47","author":[{"given":"Cheng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Wuhan Sports University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Ma","sequence":"additional","affiliation":[{"name":"College of International Education, Wuhan Sports University, Hubei Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School, Wuhan Sports University, Hubei Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine & Research Centre of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"bibr1-0363546519849657","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00009"},{"key":"bibr2-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512453300"},{"key":"bibr3-0363546519849657","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4233"},{"key":"bibr4-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510390780"},{"key":"bibr5-0363546519849657","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.629"},{"key":"bibr6-0363546519849657","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00200"},{"key":"bibr7-0363546519849657","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00394"},{"key":"bibr8-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.04.003"},{"key":"bibr9-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22505"},{"key":"bibr10-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-4020-0"},{"key":"bibr11-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.09.011"},{"key":"bibr12-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.025"},{"key":"bibr13-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.009"},{"key":"bibr14-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516651863"},{"key":"bibr15-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653964"},{"key":"bibr16-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21292"},{"key":"bibr17-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2008.01.009"},{"key":"bibr18-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071910-124656"},{"key":"bibr19-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-5-59"},{"key":"bibr20-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518795895"},{"key":"bibr21-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21301"},{"key":"bibr22-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24158"},{"key":"bibr23-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.10.006"},{"key":"bibr24-0363546519849657","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2017.00089"},{"issue":"1","key":"bibr25-0363546519849657","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jor.20948","volume":"28","author":"Qin L","year":"2010","journal-title":"J Orthop Res"},{"key":"bibr26-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2011.02.008"},{"key":"bibr27-0363546519849657","doi-asserted-by":"publisher","DOI":"10.2217\/rme.12.82"},{"key":"bibr28-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512442924"},{"key":"bibr29-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1038\/srep36715"},{"key":"bibr30-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.05.039"},{"key":"bibr31-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0447-5"},{"key":"bibr32-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-009-0793-2"},{"key":"bibr33-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0433-7"},{"key":"bibr34-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.04.022"},{"key":"bibr35-0363546519849657","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1950"},{"key":"bibr36-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.019"},{"key":"bibr37-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.107"},{"key":"bibr38-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514541539"},{"key":"bibr39-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.005"},{"key":"bibr40-0363546519849657","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111780"},{"key":"bibr41-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.11.021"},{"key":"bibr42-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516637603"},{"key":"bibr43-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070405"},{"key":"bibr44-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.64.BJR-2017-0268.R1"},{"key":"bibr45-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3733"},{"key":"bibr46-0363546519849657","doi-asserted-by":"publisher","DOI":"10.1002\/term.2258"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546519849657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0363546519849657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0363546519849657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:48:35Z","timestamp":1777369715000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0363546519849657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/0363546519849657"],"URL":"https:\/\/doi.org\/10.1177\/0363546519849657","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,31]]}}}