{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:07:19Z","timestamp":1787018839993,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The healing failure rate after rotator cuff repair is considerably high.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effect of a porous suture containing transforming growth factor beta 1 (TGF-\u03b21) on the sustained release of TGF-\u03b21 and rotator cuff healing in a rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A porous suture was developed, and its tensile strength was measured. TGF-\u03b21 was delivered using the porous suture, and a TGF-\u03b21 release test and human fibroblast proliferation assay were performed. For the animal experiment, 30 rats were randomly allocated into 3 groups (n = 10 each). A bilateral supraspinatus tendon tear was made in all the rats, and repair was performed. Group 1 received repair only; group 2, repair and a single injection of TGF-\u03b21; and group 3, repair using the porous suture containing TGF-\u03b21. Eight weeks after repair, biomechanical and histological analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The porous suture was successfully developed with mechanical properties compatible with the conventional suture, and the sustained release of TGF-\u03b21 from the porous suture was confirmed. In addition, the cell proliferation assay confirmed the biological safety of the porous suture. In the animal experiment, group 3 biomechanically exhibited the largest cross-sectional area and the highest ultimate failure load and ultimate stress (all P &lt; .05). Histological examination revealed that group 3 showed significantly better collagen fiber density and tendon-to-bone maturation than did groups 1 and 2 (all P &lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The porous suture containing TGF-\u03b21 could sustainedly and safely release TGF-\u03b21, and its use during rotator cuff repair could improve rotator cuff healing, as assessed on the basis of the biomechanical and histological changes in the rat model in this study. Considering the effectiveness, safety, and convenience of the porous suture without extra effort in surgery, the findings of the present study will have a far-reaching effect on the treatment of rotator cuff tears.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>The porous suture containing TGF-\u03b21 might improve healing after rotator cuff repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465211028547","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:54:00Z","timestamp":1626872040000},"page":"3050-3058","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of a Porous Suture Containing Transforming Growth Factor Beta 1 on Healing After Rotator Cuff Repair in a Rat Model"],"prefix":"10.1177","volume":"49","author":[{"given":"Jong Pil","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hun-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Functional Materials R&D Group, Korea Dyeing and Finishing Technology Institute, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Bio-fibers and Materials Science, College of Agriculture and Life Science, Kyungpook National University, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Rim","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Bio-fibers and Materials Science, College of Agriculture and Life Science, 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