{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:21:46Z","timestamp":1794284506432,"version":"4.9.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although presoaking grafts in vancomycin has been demonstrated to be effective in observational studies for anterior cruciate ligament reconstruction (ACLR) infection prevention, the economic benefit of the technique is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To 1) determine the cost-effectiveness of vancomycin presoaking during primary ACLR to prevent postoperative joint infections and 2) to establish the break-even cost-effectiveness threshold of the technique and determine its cost-effectiveness across various international health care settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Economic and decision analysis; Level of evidence, 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A Markov model was used to determine cost-effectiveness and the incremental cost-effectiveness ratio of additional vancomycin presoaking compared with intravenous antibiotic prophylaxis alone. A repeated search of the PubMed, SCOPUS, and Cochrane Central Register of Controlled Trials databases, using the same criteria as a recent meta-analysis, was completed. A repeated meta-analysis of 9 cohort studies (level 3 evidence) was completed to determine the odds ratio of infection with vancomycin presoaking compared with intravenous antibiotics alone. Estimated costs of the vancomycin technique, treatment of infection, and further surgery were sourced from local hospitals and literature. Transitional probabilities for further surgery, including revision reconstruction and primary arthroplasty, were obtained from the literature. Probabilistic sensitivity analyses and a 1-way sensitivity analysis were performed to evaluate the ACLR infection rate break-even threshold for which the vancomycin technique would be no longer cost-effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The vancomycin soaking technique provides expected cost savings of $660 (USA), A$581 (Australia), and \u20ac226 (Spain) per patient. There was an improvement in the quality-adjusted life-years of 0.007 compared with intravenous antibiotic prophylaxis alone (4.297 vs 4.290). If the infection rate is below 0.014% with intravenous antibiotics alone, the vancomycin wrap would no longer be cost-effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The vancomycin presoaking technique is a highly cost-effective method to prevent postoperative septic arthritis after primary ACLR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465211073338","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T12:28:20Z","timestamp":1645187300000},"page":"922-931","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Vancomycin Soaking Is Highly Cost-Effective in Primary ACLR Infection Prevention: A Cost-Effectiveness Study"],"prefix":"10.1177","volume":"50","author":[{"given":"Anthony P.","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Toowoomba Base Hospital & Gold Coast University Hospital, Toowoomba, Queensland, Australia"},{"name":"School of Medicine, Griffith University, Gold Coast, Queensland, Australia"},{"name":"School of Medicine, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"P\u00e9rez-Prieto","sequence":"additional","affiliation":[{"name":"ICATKNEE, Hospital Universitari Dexeus, Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Byrnes","sequence":"additional","affiliation":[{"name":"Centre for Applied Health Economics, Menzies Health Institute Queensland, School of Medicine and Dentistry, Griffith University, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C.","family":"Monllau","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Barcelona, Spain"},{"name":"Department of Orthopaedic Surgery and Traumatology, Hospital del Mar ICATKNEE, Hospital Universitari Dexeus, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Vertullo","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery & Sports Medicine Centre, Gold Coast, Queensland, Australia"},{"name":"Knee Research Australia, Gold Coast, Queensland, Australia"},{"name":"Menzies Health, Griffith University, Brisbane, Queensland, Australia"},{"name":"Australian Knee Society"},{"name":"Australian Orthopaedic Association"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"issue":"1","key":"bibr1-03635465211073338","first-page":"10","volume":"8","author":"Asociaci\u00f3n Espa\u00f1ola de Artroscopia JD","year":"2001","journal-title":"Rev Esp Artrosc Cir Articul"},{"key":"bibr2-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520981570"},{"key":"bibr3-03635465211073338","unstructured":"Australian Government Department of Health. Pharmaceutical Benefits Scheme (PBS) | PBS Medicine Search. Accessed May 23, 2020. http:\/\/www.pbs.gov.au\/pbs\/search"},{"key":"bibr4-03635465211073338","unstructured":"Australian Government Department of Health Human Services Australia. Medicare Australia - Statistics - Item reports. Accessed July 4, 2020. http:\/\/medicarestatistics.humanservices.gov.au\/statistics\/mbs_item.jsp"},{"key":"bibr5-03635465211073338","unstructured":"Australian Institute of Health and Welfare. Deaths in Australia. Published June 25, 2021. Accessed January 17, 2022. https:\/\/www.aihw.gov.au\/reports\/life-expectancy-death\/deaths-in-australia"},{"key":"bibr6-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-06040-2"},{"key":"bibr7-03635465211073338","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.00270"},{"key":"bibr8-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-05879-9"},{"key":"bibr9-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.12.013"},{"key":"bibr10-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1136\/jisakos-2018-000264"},{"key":"bibr11-03635465211073338","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-21-11-647"},{"key":"bibr12-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517721685"},{"key":"bibr13-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2014.03.011"},{"key":"bibr14-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119871038"},{"key":"bibr15-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/03635465030310011501"},{"key":"bibr16-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511426088"},{"key":"bibr17-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514548164"},{"key":"bibr18-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X08315247"},{"key":"bibr19-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-04004-w"},{"key":"bibr20-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2019.04.008"},{"key":"bibr21-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2005.12.002"},{"key":"bibr22-03635465211073338","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00925"},{"key":"bibr23-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.08.246"},{"key":"bibr24-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.10.040"},{"key":"bibr25-03635465211073338","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00393"},{"key":"bibr26-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096667"},{"key":"bibr27-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.12.026"},{"key":"bibr28-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513490665"},{"key":"bibr29-03635465211073338","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01705"},{"key":"bibr30-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05436-z"},{"key":"bibr31-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05353-1"},{"key":"bibr32-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1405158"},{"key":"bibr33-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-5323-6"},{"key":"bibr34-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001590"},{"key":"bibr35-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5333-6"},{"key":"bibr36-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04805-5"},{"key":"bibr37-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-017-4735-z"},{"key":"bibr38-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-014-3438-y"},{"issue":"4","key":"bibr39-03635465211073338","first-page":"309","volume":"30","author":"P\u00e9rez-Prieto D","year":"2017","journal-title":"J Knee Surg"},{"key":"bibr40-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3558-z"},{"key":"bibr41-03635465211073338","unstructured":"Royal Australasian College of Surgeons, Medibank. Surgical Variance Reports\u2014Orthopaedic Procedures 2017. Accessed January 17, 2022. http:\/\/www.surgeons.org\/policies-publications\/publications\/surgical-variance-reports\/"},{"key":"bibr42-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.04.005"},{"key":"bibr43-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-9111(02)71933-X"},{"key":"bibr44-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5278-9"},{"key":"bibr45-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516629944"},{"key":"bibr46-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.02.015"},{"key":"bibr47-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-05882-0"},{"key":"bibr48-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462300105094"},{"key":"bibr49-03635465211073338","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00560"},{"key":"bibr50-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-012-2264-3"},{"key":"bibr51-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.02.002"},{"key":"bibr52-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.08.301"},{"key":"bibr53-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmart.2020.05.005"},{"key":"bibr54-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2648-z"},{"key":"bibr55-03635465211073338","unstructured":"World Bank. Life expectancy at birth, total (years). World Development Indicators. 2019. Accessed January 23, 2021. https:\/\/data.worldbank.org\/indicator\/SP.DYN.LE00.IN?view=chart"},{"key":"bibr56-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.12.212"},{"key":"bibr57-03635465211073338","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-06265-1"},{"key":"bibr58-03635465211073338","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00974"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465211073338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03635465211073338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465211073338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:49:12Z","timestamp":1777369752000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03635465211073338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/03635465211073338"],"URL":"https:\/\/doi.org\/10.1177\/03635465211073338","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]}}}