{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:25:38Z","timestamp":1789536338749,"version":"build-2803163510"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Health & Welfare","award":["HI15C0963"],"award-info":[{"award-number":["HI15C0963"]}]},{"name":"Ministry of Health & Welfare","award":["HI20C0067"],"award-info":[{"award-number":["HI20C0067"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00210901"],"award-info":[{"award-number":["RS-2023-00210901"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Costal chondrocyte\u2013derived pellet-type autologous chondrocyte implantation (CCP-ACI) has been introduced as a new therapeutic option for the treatment of articular cartilage defects. We had previously conducted a randomized controlled trial comparing CCP-ACI versus microfracture at 1 year postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of CCP-ACI versus microfracture for the treatment of articular cartilage defects of the knee at 5 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Randomized controlled trial; Level of evidence, 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study describes the mean 5-year follow-up of a previously published prospective clinical trial. The previous prospective trial compared the results of CCP-ACI versus microfracture until 1 year of follow-up. Of the 30 patients who were included in the previous study, 25 were followed up for 5 years. Patients were evaluated based on clinical outcome scores (Lysholm score, International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score [KOOS], and visual analog scale for pain), magnetic resonance imaging findings, and rates of treatment failure at last follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score in the CCP-ACI group was significantly higher than that in the microfracture group at 5 years (62.3 vs 26.7, respectively; P &lt; .0001). The Lysholm score and KOOS score in the CCP-ACI group were significantly higher than those in the microfracture group at 5 years (84.5 vs 64.9, respectively, and 390.9 vs 303.0, respectively; P = .023 and P = .017, respectively). There was 1 case of treatment failure that occurred in the microfracture group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present randomized controlled trial indicated that the results of both procedures clinically and statistically significantly improved at 1 and 5 years\u2019 follow-up in treating cartilage defects, but the results of CCP-ACI were superior to those of microfracture. Magnetic resonance imaging conducted at 1 year and 5 years after CCP-ACI revealed statistically significant superior structural integration with native cartilage tissue compared with microfracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>NCT03545269 (ClinicalTrials.gov)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465231222797","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T08:03:41Z","timestamp":1705478621000},"page":"362-367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Costal Chondrocyte\u2013Derived Pellet-Type Autologous Chondrocyte Implantation Versus Microfracture for the Treatment of Articular Cartilage Defects: A 5-Year Follow-up of a Prospective Randomized Trial"],"prefix":"10.1177","volume":"52","author":[{"given":"Kyoung-Ho","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Kyung-Hee University Hospital, Kyung-Hee University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungsun","family":"Lee","sequence":"additional","affiliation":[{"name":"R&D Institute, Biosolution, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-9157","authenticated-orcid":false,"given":"Jae-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"bibr1-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509351143"},{"key":"bibr2-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513485931"},{"key":"bibr3-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518756976"},{"key":"bibr4-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000462"},{"key":"bibr5-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513510140"},{"key":"bibr6-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2676-8"},{"key":"bibr7-03635465231222797","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200710000-00002"},{"key":"bibr8-03635465231222797","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.01208"},{"key":"bibr9-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508323256"},{"key":"bibr10-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517701912"},{"key":"bibr11-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2304-9"},{"key":"bibr12-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508328414"},{"key":"bibr13-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05359-9"},{"key":"bibr14-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200111)44:11<2586::AID-ART439>3.0.CO;2-I"},{"key":"bibr15-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/2325967117704634"},{"key":"bibr16-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.04.071"},{"key":"bibr17-03635465231222797","first-page":"419","volume":"56","author":"Williams RJ","year":"2007","journal-title":"Instr Course Lect"},{"key":"bibr18-03635465231222797","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520921448"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465231222797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03635465231222797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465231222797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:50:17Z","timestamp":1777369817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03635465231222797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/03635465231222797"],"URL":"https:\/\/doi.org\/10.1177\/03635465231222797","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}