{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:00:53Z","timestamp":1782507653538,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Synovial fluid (SF) biomarkers demonstrate time-dependent variation after acute knee injury, and it is postulated that persistently elevated inflammatory markers may mediate worse long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study investigated the relationship between biomarkers in SF at the time of meniscectomy and long-term patient-reported outcomes in patients with acute versus chronic meniscal injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Cohort study; Level of evidence, 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective analysis included patients who underwent knee SF aspiration on the day of arthroscopic meniscectomy between October 2011 and October 2020 with minimum 4-year follow-up. SF aspirated from the operative knee was analyzed for 10 pro- and anti-inflammatory biomarkers. Patients completed the visual analog scale for pain, Lysholm Knee Questionnaire, Tegner Activity Scale, and Knee injury and Osteoarthritis Outcome Score\u2013Physical Function Short-form (KOOS-PS) before surgery and at follow-up. Patients were categorized as having acute (&lt;6 weeks) or chronic (&gt;1 year) symptoms. K-means clustering analysis was performed using biomarker levels to group patients into distinct cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 85 patients meeting inclusion criteria, 55 had chronic and 30 had acute meniscal pathology, with 62 (72.9%) completing patient-reported outcome surveys at a mean follow-up of 8.66 years (SD, 2.27). K-means clustering identified 2 distinct biomarker profiles: a high-inflammation cluster and a low-inflammation cluster. The high-inflammation cluster had higher levels of 7 proinflammatory biomarkers as compared with the low-inflammation cluster (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .015). The low-inflammation cluster predominantly comprised chronic meniscal injuries (89.2%), whereas the high-inflammation cluster was divided between acute and chronic cases. There were no differences in postoperative outcomes between clusters in the overall cohort. However, within the chronic cohort, the high-inflammation cluster exhibited worse postoperative scores on the visual analog scale for pain (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .035), Lysholm questionnaire (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007), KOOS-PS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .038), and Tegner scale (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .049) and had a higher rate of postoperative injections (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .020) than the low-inflammation cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with chronic meniscal injury, those with a more proinflammatory SF biomarker profile at the time of meniscectomy had worse outcomes than those who had a low inflammatory profile. In acute meniscal injuries, most patients demonstrate a high inflammatory profile, which was not associated with a difference in long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251343306","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T02:36:57Z","timestamp":1748831817000},"page":"1960-1968","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Proinflammatory Synovial Fluid Biomarkers Predict Poor Long-term Outcomes in Chronic Meniscal Injuries"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4631-4737","authenticated-orcid":false,"given":"Emily","family":"Berzolla","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2691-1019","authenticated-orcid":false,"given":"Vishal","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pianka","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, USA"},{"name":"Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, NYU Langone, New York, New York, 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