{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:08:04Z","timestamp":1779271684366,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University (number 40364).","award":["40364"],"award-info":[{"award-number":["40364"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anterior cruciate ligament (ACL) injuries are prevalent among athletes and the general population, with ACL reconstruction (ACLR) being the standard treatment. However, effective tendon-bone healing (TBH) remains a challenge. Hydroxyapatite (HAp), widely used in orthopaedics and dentistry, has yet to be fully explored for its potential to enhance TBH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>HAp-coated, reinforced, nonabsorbable suture materials can act as a bioactive and osteoinductive bridge, expediting TBH after ACLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Gelatin-based solutions were used to coat suture materials with HAp, forming stable layers analyzed via scanning electron microscopy and energy-dispersive spectrum. Sixteen New Zealand rabbits underwent extra-articular TBH modeling, with the right knee as the experimental group and the left as the control. Evaluations were conducted at 6 and 12 weeks, including histomorphometry, microcomputed tomography (micro-CT) for bone formation and mineral density, and tensile testing to assess mechanical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Histological analysis demonstrated significantly higher bone\/fibrous interzone area ratios in the experimental group at the 6th week (1.24 \u00b1 0.14 vs 0.45 \u00b1 0.18;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .011) and 12th week (2.07 \u00b1 0.47 vs 0.74 \u00b1 0.11;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .013). Circumferential bone formation at the 6th week was markedly greater in the experimental group (89.17% \u00b1 5.97% vs 29.66% \u00b1 10.05%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .012). Micro-CT showed increased bone mineral density (2.09 \u00b1 0.41 vs 1.35 \u00b1 0.36;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .037) and reduced bone tunnel circumference at the 12th week. Biomechanical tests indicated greater stiffness (4.22 \u00b1 1.33 vs 3.18 \u00b1 0.76;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .044), with no significant differences in failure load or displacement at the 12th week.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HAp-coated sutures significantly improved TBH (particularly histological results at the 6th week), enhancing bone integration and mechanical properties in the extra-articular TBH model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>The use of HAp-coated nonabsorbable polyfilament sutures may enhance TBH. Early histological evaluations indicated a positive effect on TBH, which was further corroborated by radiological and biomechanical improvements. These findings warrant further clinical investigation to explore potential applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251358472","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T21:29:35Z","timestamp":1755293375000},"page":"2633-2641","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Hydroxyapatite-Coated, Reinforced, Nonabsorbable Polyfilament Suture Material on Tendon-Bone Healing"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-7497","authenticated-orcid":false,"given":"Mustafa","family":"Ozkaya","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Faculty of Medicine, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9832-8140","authenticated-orcid":false,"given":"Taha","family":"Kizilkurt","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Faculty of Medicine, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengisu","family":"Kubasik","sequence":"additional","affiliation":[{"name":"Institute of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilge","family":"Bilgic","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Istanbul University Faculty of Medicine, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgul","family":"Gok","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Sciences, Biomedical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Faculty of Medicine, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465010290060301"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02281-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2019.05.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354659402200309"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0584-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506286866"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.07.010"},{"key":"e_1_3_2_10_2","first-page":"7333","article-title":"Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon\u2013bone interface healing for anterior cruciate ligament reconstruction","volume":"10","author":"Han F","year":"2015","unstructured":"Han F, Zhang P, Sun Y, Lin C, Zhao P, Chen J. 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