{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:47:32Z","timestamp":1793710052474,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P50AR060752-02"],"award-info":[{"award-number":["5P50AR060752-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Quantitative magnetic resonance imaging (qMRI), such as T1\u03c1 and T2 mapping, allows for the characterization of the biochemical composition of cartilage and the detection of early degeneration within 1 year after anterior cruciate ligament reconstruction (ACLR). It remains unclear if early imaging biomarkers are associated with the long-term development of posttraumatic osteoarthritis (PTOA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Purpose:<\/jats:title>\n                    <jats:p>The study aimed to investigate the relationship between qMRI-based evaluation of the medial compartment at baseline and 1 year after ACLR and the knee joint morphological status using 3-dimensional (3D) MRI at a 10-year follow-up. It was hypothesized that elevated T1p and T2 values at 1 year after ACLR would correlate with increased degenerative joint disease at 10 years after ACLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Cohort study; Level of evidence, 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients with ACLR between 2011 and 2014 who had preoperative bilateral qMRI were included. Thirteen patients completed the 10-year follow-up and were evaluated. The mean T1\u03c1 and T2 values at baseline and 1 year were obtained using in-house\u2013developed software with MATLAB. The MRI scans at the 10-year follow-up were acquired using a 3-T MRI scanner, including bilateral 3D proton-density fat-saturated fast-spin-echo sequence. Two radiologists used the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) to grade the images. The correlations between baseline, 1-year, and delta (1 year \u2013 baseline) T1\u03c1\/T2 values and the WORMS at 10 years postoperatively were analyzed using the Spearman correlation coefficient. Significance was defined as a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt;.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The baseline, 1-year, and delta medial tibia (MT) T1\u03c1 values were significantly associated with the 10-year WORMS Total Score (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.604,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .031;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.604,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .031; and\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.582,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .039, respectively). The MT T2 value at 1 year postoperatively was significantly associated (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.566;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .046) with the 10-year WORMS Total Score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The T1\u03c1\/T2 values 1 year postoperatively and the increase from baseline to 1 year in the MT cartilage after ACLR were associated with the deterioration of the comprehensive evaluation of the knee at 10 years postoperatively. These findings help establish qMRI as a valuable biomarker for detecting early signs of PTOA progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251360800","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T07:00:37Z","timestamp":1756710037000},"page":"2562-2570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationship Between Early Cartilage Degeneration With T1\u03c1 and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-1991","authenticated-orcid":false,"given":"Shotaro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine &amp; Shoulder Surgery, University of California, San Francisco, San Francisco, California, USA"},{"name":"Department of Orthopaedic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Center for Preventive Medical Sciences, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Kaibara","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine &amp; Shoulder Surgery, University of California, San Francisco, San Francisco, California, USA"},{"name":"Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Benjamin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine &amp; Shoulder Surgery, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Kreutzinger","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ziegeler","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupsa","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Feeley","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine &amp; Shoulder Surgery, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-6776","authenticated-orcid":false,"given":"Drew A.","family":"Lansdown","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine &amp; Shoulder Surgery, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516677794"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967116644421"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.05.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.08.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.02.623"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/19417381231205276"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520980431"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.12.11"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.06.014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.04.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3469"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2035616"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.02.001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.09.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21414"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21877"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25065"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20536"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23277"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3645-2"},{"key":"e_1_3_3_24_2","first-page":"7","article-title":"Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease","author":"Shamonin D","year":"2014","unstructured":"Shamonin D, Bron E, Lelieveldt B, Smits M, Klein S, Staring M. Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease. Front Neuroinform. 2014;7.","journal-title":"Front Neuroinform"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.01.050"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.07.033"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-008-0491-y"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.05.010"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.985"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.031"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2397-z"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/19476035241264013"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2013.12.010"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241305734"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/23259671241307672"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22867"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.07.012"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465251360800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03635465251360800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465251360800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:23:48Z","timestamp":1779269028000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03635465251360800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/03635465251360800"],"URL":"https:\/\/doi.org\/10.1177\/03635465251360800","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}