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Baseline and 2-year magnetic resonance imaging scans of the knee were evaluated for progressive PF cartilage damage using the Magnetic Resonance Imaging Osteoarthritis Knee Score. Tibial tubercle\u2013trochlear groove (TT-TG) distance, patellar tilt, external tibiofemoral rotation (eTFR), patellar height, entry point\u2013trochlear groove angle, and entry point\u2013transition point (EP-TP) angle were measured for each knee. To assess the association of each morphology measure with progressive cartilage damage, logistic regression models with generalized estimating equations were fit using continuous and natural cubic spline models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We analyzed lateral PF cartilage damage in 389 knees (mean age, 53.79 \u00b1 5.51 years; mean body mass index, 28.48 \u00b1 5.13 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). TT-TG distance (\u03b2 = 0.23; odds ratio, 1.26;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .036), eTFR (\u03b2 = 0.24; odds ratio, 1.27;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .048), and EP-TP angle (\n                      <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                      = 2.09;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .036) all demonstrated significant positive associations with worsening lateral PF cartilage damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results demonstrated significant associations between 3-dimensional anatomic metrics and progressive lateral PF cartilage damage. Elevated TT-TG distance, eTFR, and EP-TP angle may be keys to understanding the mechanical cause of lateral PF osteoarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251367716","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:49:52Z","timestamp":1757681392000},"page":"2881-2888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Measures of Patellofemoral Morphology Predict the Risk of Local Cartilage Damage Progression: A Yale\/MOST Collaborative Study"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-1507","authenticated-orcid":false,"given":"Nancy","family":"Park","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-3442","authenticated-orcid":false,"given":"Johannes M.","family":"Sieberer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA"},{"name":"Department of Mechanical Engineering, Yale School of Engineering and Applied Science, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"McGinley","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-7942","authenticated-orcid":false,"given":"Armita R.","family":"Manafzadeh","sequence":"additional","affiliation":[{"name":"Institute for Biospheric Studies, Yale University, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Kansas Medical Center, Kansas City, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston University Chobanian &amp; 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