{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:08:04Z","timestamp":1779271684449,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">\n                      The anterior cruciate ligament reconstruction (ACLR) graft undergoes a remodeling process that affects its structural properties. Ultrashort echo time T\n                      <jats:sub>2*<\/jats:sub>\n                      (UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      ) imaging has been instrumental in examining this process. However, more research is needed on the postoperative relationship between UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      of the graft and its mechanical properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">\n                      To longitudinally examine ACL graft changes after ACLR using UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      decay coefficients and knee laxity and explore their relationship.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">Case series; Level of evidence, 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">\n                      A total of 31 patients who underwent ACLR had magnetic resonance imaging of their knees at 1, 6, and 12 months after surgery using a UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      sequence. Bilateral knee laxity was measured at 6 and 12 months using a GNRB arthrometer (force = 200 N). UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      coefficients of the graft were calculated using mono- (T\n                      <jats:sub>2m*<\/jats:sub>\n                      ) and biexponential (short [T\n                      <jats:sub>2s*<\/jats:sub>\n                      ] and long [T\n                      <jats:sub>2l*<\/jats:sub>\n                      ]) analyses, and outcomes were normalized to body mass index. Linear mixed models were used to determine longitudinal changes in UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      and laxity; the Pearson correlation was used to explore the correlations between these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">\n                      T\n                      <jats:sub>2m*<\/jats:sub>\n                      of the graft increased from 1 to 6 months (\u0394 = 0.092;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008), followed by a decrease from 6 to 12 months (\u0394 = \u22120.079;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .021). Regardless of the limb side, a decrease in laxity was detected between 6 and 12 months after surgery (\u0394 = \u22120.033;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .046). Positive correlations between laxity and UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      were detected at 6 months (T\n                      <jats:sub>2s*<\/jats:sub>\n                      :\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      = 0.285;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .025) and 12 months (T\n                      <jats:sub>2m*<\/jats:sub>\n                      :\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      = 0.532;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01; T\n                      <jats:sub>2s*<\/jats:sub>\n                      :\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      = 0.669;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001; T\n                      <jats:sub>2l*<\/jats:sub>\n                      :\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      = 0.354;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p content-type=\"TEXT\">\n                      Biexponential analysis of UTE-T\n                      <jats:sub>2*<\/jats:sub>\n                      MRI provides a sensitive tool for detecting structural changes in the graft after ACL reconstruction, reflecting the dynamic process of graft remodeling. Among the decay coefficients assessed, T\n                      <jats:sub>2s*<\/jats:sub>\n                      demonstrates a stronger correlation with postoperative laxity, highlighting its potential as a critical biomarker for monitoring graft integrity over time.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251368393","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T12:22:39Z","timestamp":1758284559000},"page":"2841-2850","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship Between Quantitative MRI UTE T2* of ACL Autografts and BMI-Normalized Knee Laxity Within the First Year After ACL Reconstruction"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4356-1569","authenticated-orcid":false,"given":"Alonso","family":"Figueroa","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas, Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-2463","authenticated-orcid":false,"given":"Tomasz","family":"Bugajski","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas, Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1203-437X","authenticated-orcid":false,"given":"Dillon","family":"Humpal","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas, Health Science Center at Houston, Houston, Texas, 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