{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:58:32Z","timestamp":1793793512177,"version":"4.6.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lateral epicondylitis, commonly known as tennis elbow, is a prevalent musculoskeletal disorder characterized by pain and functional impairment. Platelet-rich plasma (PRP) has been proposed as a regenerative treatment, but its efficacy remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of PRP in improving pain and function in patients with lateral epicondylitis as compared with placebo through a systematic review and meta-analysis of randomized clinical trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis of RCTs; Level of evidence: 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed, Scopus, Embase, and Cochrane CENTRAL for RCTs comparing PRP with placebo in lateral epicondylitis. Primary outcomes included pain relief and functional improvement assessed at multiple time points (4, 8-12, and 24-26 weeks). Secondary outcomes included adverse events and grip strength. Statistical analyses used standardized mean difference (SMD), mean difference (MD), and risk ratios with 95% confidence intervals (95% CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Six RCTs with 355 patients were included. PRP did not provide significant pain relief at 4 weeks (SMD, 0.08; 95% CI, \u20130.17 to 0.34;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .526), 8 to 12 weeks (SMD, \u20130.36; 95% CI, \u20130.99 to 0.27;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .263), or 24 to 26 weeks (MD, \u20131.58; 95% CI, \u20134.74 to 1.58;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .328). Functional improvement was also not significantly different at 4 weeks (SMD, 0.09; 95% CI, \u20130.18 to 0.37;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .518), 12 weeks (SMD, \u20130.09; 95% CI, \u20130.39 to 0.21;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .565), or 24 to 26 weeks (SMD, 0.13; 95% CI, \u20130.18 to 0.43;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .413). No significant difference was found in adverse events (risk ratio, 1.66; 95% CI, 0.65-4.19;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .287).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PRP does not provide significant pain relief or functional improvement in patients with lateral epicondylitis in the current study of available RCTs as compared with placebo at all evaluated time points. These findings do not support PRP as a recommended treatment for this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251383039","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:00:46Z","timestamp":1767942046000},"page":"1247-1257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelet-Rich Plasma Does Not Improve Pain or Function in Patients With Lateral Epicondylitis as Compared With Placebo: A Meta-analysis of Randomized Clinical Trials"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-5279","authenticated-orcid":false,"given":"C\u00e9sar Romero","family":"Antunes J\u00fanior","sequence":"first","affiliation":[{"name":"Federal University of Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-1874","authenticated-orcid":false,"given":"Ramon Sampaio Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4688-8857","authenticated-orcid":false,"given":"Eduardo Silva Reis","family":"Barreto","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4271-7543","authenticated-orcid":false,"given":"Guilherme Neves","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewerton Borges de Souza","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique Schmidt","family":"Lara","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto de Castro","family":"Pochini","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Vicente","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Ejnisman","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Santoro","family":"Belangero","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251111"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2017.11.033"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10195-015-0376-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030995"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/17581869.2024.2360381"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40945-019-0063-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000003349"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200801000-00004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01374"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517743746"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61160-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2019.08.005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000961"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516643716"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442106"},{"issue":"9","key":"e_1_3_2_17_2","article-title":"Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain","volume":"9","author":"Karjalainen TV","year":"2021","unstructured":"Karjalainen TV, Silagy M, O\u2019Bryan E, Johnston RV, Cyril S, Buchbinder R. 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