{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:51:05Z","timestamp":1793314265788,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007146","name":"Allgemeine Unfallversicherungsanstalt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite technical innovations and surgical improvements, retear rates after arthroscopic rotator cuff (RC) repair remain high. Preclinical studies demonstrated improved outcomes using bisphosphonates after RC repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose\/Hypothesis:<\/jats:title>\n                    <jats:p>The purpose of this monocentric, prospective, randomized, placebo-controlled, triple-blinded phase II trial was to investigate retears in patients without osteoporosis undergoing arthroscopic RC repair with a systemic single-dose zoledronic acid. It was hypothesized that zoledronic acid would reduce retears after RC repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Randomized controlled trial; Level of evidence, 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 80 patients were intraoperatively randomized to the zoledronic acid group (n = 40) or the control group (n = 40). All patients underwent magnetic resonance imaging 6 months after surgery. Range of motion, abduction strength, Constant-Murley score (CMS), American Shoulder and Elbow Surgeons (ASES) score, Subjective Shoulder Value (SSV), and Visual Analog Scale (VAS) for pain were assessed preoperatively as well as 3 and 6 months after arthroscopic RC repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 6 months, retears were significantly lower (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) in the zoledronic acid group (n = 6; 15%) compared with the control group (n = 14; 35%). The risk of a RC retear with an additional zoledronic acid treatment (RR, 0.43 [95% CI, 0.16; 0.98]) was significantly lower compared with that of the control group (OR, 0.328; 95% CI, 0.111-0.969;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .044). Postoperative fatty muscle infiltration of the supraspinatus was significantly lower in the zoledronic acid group compared with the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Clinical and functional outcomes significantly improved in the 2 study groups 3 and 6 months postoperatively, with better outcomes for abduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002), forward flexion (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002), external rotation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001), CMS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), ASES score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), SSV (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and VAS for pain (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) in the zoledronic acid group at the final follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An intraoperative systemic single-dose zoledronic acid reduced retears after arthroscopic RC repair. Zoledronic acid is a safe, easy-to-apply, and cost-effective augmentation technique for patients undergoing arthroscopic RC repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>NCT05677152 (ClinicalTrials.gov identifier).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465251399167","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:03:13Z","timestamp":1768802593000},"page":"342-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Intraoperative Zoledronic Acid for Arthroscopic Rotator Cuff Repair: Short-Term Results From a Prospective, Randomized, Placebo-Controlled Phase II Trial"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-5551","authenticated-orcid":false,"given":"Jakob E.","family":"Schanda","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, AUVA Trauma Center Vienna\u2013Meidling, Vienna, Austria"},{"name":"Ludwig Boltzmann Institute for Traumatology \u2013 The Research Center in Cooperation with AUVA, Vienna, Austria"},{"name":"Austrian Cluster for Tissue Regeneration, Vienna, Austria"},{"name":"healthPi Medical Center, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, AUVA Trauma Center Vienna\u2013Meidling, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-6833","authenticated-orcid":false,"given":"Sandra","family":"Boesmueller","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, AUVA Trauma Center Vienna\u2013Meidling, Vienna, 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