{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:38:31Z","timestamp":1789612711648,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004735","name":"natural science foundation of hunan province","doi-asserted-by":"publisher","award":["2019JJ30035"],"award-info":[{"award-number":["2019JJ30035"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"natural science foundation of hunan province","doi-asserted-by":"publisher","award":["2024JJ9212"],"award-info":[{"award-number":["2024JJ9212"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81902221"],"award-info":[{"award-number":["81902221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Healing of the tendon-bone interface (TBI) after rotator cuff injury is limited, often leading to scar-mediated repair. Decellularized tendon fibrocartilage\u2013bone composite (dTFBC) and bone marrow mesenchymal stem cell sheets (BMSCS) improve repair in preclinical models, but full scaffold encapsulation with mechanical preconditioning remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate TBI regeneration using mechanically preconditioned, BMSCS-encapsulated dTFBC scaffolds in a rabbit model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 48 male New Zealand White rabbits were randomized into 4 groups (n = 12 each): (1) standard repair (control); (2) repair with dTFBC; (3) repair with dTFBC-BMSCS; and (4) repair with mechanically preconditioned dTFBC-BMSCS (mdTFBC-BMSCS). Healing at 12 weeks was assessed via gross observation, histomorphological and immunohistochemical analyses, and biomechanical testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mdTFBC-BMSCS group demonstrated a higher ultimate failure load (mean, 203.9 \u00b1 65.6 N) than both the control (118 \u00b1 37.4 N;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003) and dTFBC groups (127 \u00b1 44.1 N;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008), with no significant difference between the 2 BMSCS-treated groups. Histological analysis revealed enhanced fibrocartilage formation, improved collagen fiber organization, and reduced inflammation infiltration at the TBI in the mdTFBC-BMSCS group. Immunohistochemical analysis showed greater collagen type 2 alpha 1 chain-, interleukin 10-, and arginase 1-positive areas in the mdTFBC-BMSCS group than in the control and dTFBC groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mechanically preconditioned, fully BMSCS-encapsulated dTFBC scaffolds promoted TBI regeneration, with enhanced cellular integration, fibrocartilage formation, and favorable biomechanical performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>This biomimetic scaffold strategy may enhance biological healing and reduce the risk of retear after rotator cuff repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465261428684","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:58:52Z","timestamp":1773237532000},"page":"1679-1689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanically Preconditioned Biomimetic Gradient Scaffold for Tendon-to-Bone Regeneration in a Rabbit Rotator Cuff Tear Model"],"prefix":"10.1177","volume":"54","author":[{"given":"Yang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilihumaer","family":"Aili","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafei","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8737-4587","authenticated-orcid":false,"given":"Chunfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-5350","authenticated-orcid":false,"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00491.2012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20563"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0492"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.4031571"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.821667"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0470"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2011.11.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.12.041"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518770428"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-023-03370-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-019-00196-w"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202300070"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2696"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.10.037"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0363"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241282668"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.024"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1391"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34083"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.06.010"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201106000-00007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.725563"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1039-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520909854"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.01.070"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-018-0114-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.04.025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0659"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231171682"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.03.012"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119837"},{"key":"e_1_3_2_33_2","first-page":"443","article-title":"The basic science behind biologic augmentation of tendon-bone healing: a scientific review","volume":"63","author":"Weeks KD","year":"2014","unstructured":"Weeks KD, Dines JS, Rodeo SA, Bedi A. The basic science behind biologic augmentation of tendon-bone healing: a scientific review. Instr Course Lect. 2014;63:443-450.","journal-title":"Instr Course Lect"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512462677"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v17.i1.98349"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.657584"},{"issue":"2","key":"e_1_3_2_37_2","article-title":"Comparisons of rabbit bone marrow mesenchymal stem cell isolation and culture methods in vitro","volume":"9","author":"Zhang W","year":"2014","unstructured":"Zhang W, Zhang F, Shi H, et al. Comparisons of rabbit bone marrow mesenchymal stem cell isolation and culture methods in vitro. PLoS One. 2014;9(2):e88794.","journal-title":"PLoS One"},{"issue":"11","key":"e_1_3_2_38_2","first-page":"1087","article-title":"Risk factors for full-thickness rotator cuff tears: a systematic review and meta-analysis","volume":"6","author":"Zhao J","year":"2021","unstructured":"Zhao J, Pan J, Zeng LF, Wu M, Yang W, Liu J. Risk factors for full-thickness rotator cuff tears: a systematic review and meta-analysis. EFORT Open Rev. 2021;6(11):1087-1096.","journal-title":"EFORT Open Rev"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.01.020"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002269"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01778-6"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465261428684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03635465261428684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465261428684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:42:37Z","timestamp":1784799757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03635465261428684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/03635465261428684"],"URL":"https:\/\/doi.org\/10.1177\/03635465261428684","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}