{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:08:14Z","timestamp":1784185694517,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["82471607"],"award-info":[{"award-number":["82471607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["82472483"],"award-info":[{"award-number":["82472483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["82502878"],"award-info":[{"award-number":["82502878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rotator cuff tear is a prevalent musculoskeletal disorder with a high postoperative retear rate. Transcortical vessels (TCVs) are capillaries that cross cortical bone and represent key elements of bone microcirculation. However, the possible intervention and influence of TCVs for rotator cuff repair (RCR) have rarely been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the effect of TCV-mediated revascularization in RCR and the mechanism of potential intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sprague-Dawley rats (N = 135) with supraspinatus tendon tear and delayed repair were randomly assigned into 3 groups based on footprint preparation: (1) cortical bone freshening up by debridement to expose cancellous bone, (2) cortical bone preservation as the control group, and (3) cortical bone preservation with oral D-sphingosine as a TCV-stimulating factor. Oxidative stress was measured using fluorescent probes; hypoxia and inflammation levels were measured via immunosorbent assay; and RCR and TCVs were evaluated with biomechanical and immunostaining assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cortical bone preservation inhibited the revascularization of TCVs during RCR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01), while freshening up or D-sphingosine treatment promoted TCV formation by reducing oxidative stress (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 for all). Revascularization of TCVs alleviated hypoxia and inflammation-derived chronic tendinopathy after 6 weeks (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 for all) and improved the biomechanical properties of rotator cuff at 12 weeks (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Footprint freshening up or D-sphingosine treatment improves tendon-to-bone healing, suggesting the importance of TCV-mediated revascularization for RCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>Revascularization therapy such as cortical bone freshening up or D-sphingosine has the potential to improve RCR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465261453033","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:46:57Z","timestamp":1781081217000},"page":"2274-2285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Revascularization of Transcortical Vessels Improves Tendon-to-Bone Healing for Rotator Cuff Repair"],"prefix":"10.1177","volume":"54","author":[{"given":"Wenyang","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoutong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-1624","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404842"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-01233-y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231189201"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511402662"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-098161"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2024.06.040"},{"issue":"1","key":"e_1_3_2_8_2","first-page":"9","article-title":"Defining the cost of arthroscopic rotator cuff repair a multicenter, time-driven activity-based costing and cost optimization investigation","volume":"107","author":"Fedorka CJ","year":"2025","unstructured":"Fedorka CJ, Etges APBD, Best MJ, et al. Defining the cost of arthroscopic rotator cuff repair a multicenter, time-driven activity-based costing and cost optimization investigation. J Bone Joint Surg Am. 2025;107(1):9-15.","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-018-0016-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0274-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211014856"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13145"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514525336"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.04.004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46095-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.09.056"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07340-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518799357"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071910-124656"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00234-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2023.12.013"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adt1228"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1952-z"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106066"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13146"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01495"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3159"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231185340"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.09.014"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00602-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.07.043"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.12.003"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500144"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465261453033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03635465261453033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03635465261453033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:01:44Z","timestamp":1784185304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03635465261453033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/03635465261453033"],"URL":"https:\/\/doi.org\/10.1177\/03635465261453033","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}