{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:04:14Z","timestamp":1790431454081,"version":"4.1.0"},"reference-count":63,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Sports Med"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Posterior tibial slope (PTS) influences tibiofemoral kinematics and anterior cruciate ligament (ACL) function. While previous studies have evaluated symmetrical slope modifications, the isolated influences of the medial or lateral PTS remain unclear. This study investigated the influence of medial and lateral PTS changes on anterior tibial translation (ATT) and internal rotation (IR) under axial loading, using unicondylar slope-changing osteotomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Increased lateral PTS increases ATT, while a greater delta PTS (lateral minus medial PTS) increases IR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Controlled laboratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Eight fresh-frozen knee specimens were mounted in a custom-built fixture in a compression\/torsion loading machine. Tibiofemoral translation\/rotation kinematics were measured under a 500-N axial compression load at 0\u00b0 and 20\u00b0 of knee flexion using optical motion tracking. Unicondylar tibial slope-changing osteotomies were performed on the medial and lateral tibial plateaus with a custom cutting guide, preserving key ligament and meniscus root attachments. Medial and lateral PTS were independently adjusted to \u22125\u00b0, 0\u00b0, +5\u00b0, and +10\u00b0, resulting in medial and lateral PTS ranging from \u22125\u00b0 to +10\u00b0, using 3-dimensionally printed wedges. Repeated-measures analyses of variance, post hoc\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      tests, and Pearson correlations were used for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      An increase of +10\u00b0 in lateral PTS significantly increased ATT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .012), while increasing medial PTS did not (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .99). IR was most influenced by delta PTS. At 0\u00b0 of flexion, altering lateral or medial PTS alone was insufficient to significantly change rotation, but changing delta PTS +10\u00b0 produced 7.6\u00b0 more rotation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .015). At 20\u00b0 of flexion, changing individual slopes \u00b110\u00b0 significantly increased\/decreased rotation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .036). The largest rotational differences correlated with opposing delta PTS values (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.960;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .0006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lateral PTS was the principal determinant of ATT, whereas delta PTS was the principal determinant of IR under axial loading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>Understanding the independent biomechanical roles of the medial and lateral PTS provides insight into mechanisms of anterior and rotational instability in ACL injury and reconstruction. These findings suggest the potential utility of differential correction of PTS as a novel surgical approach for optimizing tibiofemoral rotational kinematics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03635465261480902","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:48:10Z","timestamp":1790077690000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lateral Tibial Posterior Slope Induces Anterior Tibial Translation While Lateral-Medial Slope Difference Induces Internal Rotation: A Cadaveric Biomechanical Study"],"prefix":"10.1177","author":[{"given":"Shuntaro","family":"Nejima","sequence":"first","affiliation":[{"name":"Biomechanics Group, Mechanical Engineering Department, Imperial College, London, United Kingdom"},{"name":"Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Holt","sequence":"additional","affiliation":[{"name":"Biomechanics Group, Mechanical Engineering Department, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1301-1337","authenticated-orcid":false,"given":"Richard","family":"van Arkel","sequence":"additional","affiliation":[{"name":"Biomechanics Group, Mechanical Engineering Department, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"University Hospitals Coventry and Warwickshire, Coventry, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Smith","sequence":"additional","affiliation":[{"name":"University Hospitals Coventry and Warwickshire, Coventry, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-1381","authenticated-orcid":false,"given":"Andrew","family":"Amis","sequence":"additional","affiliation":[{"name":"Biomechanics Group, Mechanical Engineering Department, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.99B3.37863"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520966327"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465251334649"},{"key":"e_1_3_3_5_2","volume-title":"Assessing the Contributions of Soft Tissue to the Stability of Total Knee Replacements","author":"Athwal KK","year":"2017","unstructured":"Athwal KK. 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