{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:18:27Z","timestamp":1777389507303,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1980,7,1]],"date-time":"1980-07-01T00:00:00Z","timestamp":331257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[1980,7]]},"abstract":"<jats:p>Despite the widespread use of phenylbutazone, its safety is still a controversial issue. One example of its toxicity is the fact that phenylbutazone has now replaced chloramphenicol as the most common cause of fatal drug-related aplastic anemia. To evaluate the toxicity of phenylbutazone as it is commonly used in sports medicine, a group of 3,000 healthy young athletes was studied following 1-week courses of phenylbutazone for various sports-related inflammatory problems. No serious adverse re actions were encountered. Four percent of the patients expe rienced mild gastrointestinal disturbances with less than 1% of the patients being forced to discontinue the medication. Com piling the results of other studies, it is estimated that the risk of a serious reaction to phenylbutazone is less than 1 per 100,000 when the drug is used by healthy young individuals for periods of 1 week or less. This risk increases significantly in older patients and with longer periods of treatment. Although phenylbutazone is widely prescribed in sports medicine, there appears to be insufficient information regarding its possible effects on athletic performance. Its capacity to cause significant fluid retention with secondary dilutional anemia, for example, could, in certain instances, have an adverse effect on overall performance if the drug is continued after the athlete returns to competition. Further study in this area is urged.<\/jats:p>","DOI":"10.1177\/036354658000800411","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T20:46:52Z","timestamp":1182458812000},"page":"270-273","source":"Crossref","is-referenced-by-count":6,"title":["Use of phenylbutazone in sports medicine: understanding the risks"],"prefix":"10.1177","volume":"8","author":[{"given":"Howard M.","family":"Black","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, U. S. Naval Academy Hospital, Annapolis, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay S.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, U. S. Naval Academy Hospital, Annapolis, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Rex","family":"Straughn","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, U. S. Naval Academy Hospital, Annapolis, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,7,1]]},"reference":[{"key":"atypb1","unstructured":"Goodman LS, Gilman A.: The Pharmacological Basis of Therapeutics. Fifth edition. New York, The MacMillan Co, 1975"},{"key":"atypb2","unstructured":"Looney DS: New uproar over a controversial drug. Sports Illustrated 48: 20-27, 1978"},{"key":"atypb3","doi-asserted-by":"crossref","unstructured":"Marshall E.: Drugging of football players curbed by central monitoring plan, NFL Claims. Science 203: 626-628, 1979","DOI":"10.1126\/science.760208"},{"key":"atypb4","unstructured":"de Gruchy GC: Drug-Induced Blood Disorders. Oxford, Blackwell Scientific Publishers, 1975"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5875.339"},{"key":"atypb6","unstructured":"Physicians Desk Reference. Thirty-third edition. New Jersey , Medical Economics Co, 1979"},{"key":"atypb7","unstructured":"Blazina ME: Oxyphenbutazone as an adjunct to the conventional treatment of athletic injuries . Clin Med 76: 19-22, 1969"},{"key":"atypb8","doi-asserted-by":"crossref","unstructured":"Fowler PD, Faragher EB: Drug and non-drug factors influencing adverse reactions to pyrazoles. J Int Med 5 Suppl (2): 108-120, 1977","DOI":"10.1177\/030006057700502S22"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6075.1500"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270100049030"},{"key":"atypb11","unstructured":"Pisciotta AV : Immune and toxic mechanisms in drug-induced agranulocytosis. Semin Hematol 10: 279-310, 1973"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1965.tb71575.x"},{"key":"atypb13","unstructured":"Fitzpatrick TB , Arndt KA, Clark Jr WH, et al: Dermatology in General Medicine. New York, McGraw Hill , 1971"},{"key":"atypb14","unstructured":"AMA Drug Evaluations. Third edition. Prepared by the American Medical Association, Department of Drugs. Littleton, MA, Publications Sciences Group, Inc, 1977"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/036354658000800411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/036354658000800411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:47:47Z","timestamp":1777369667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/036354658000800411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,7]]}},"alternative-id":["10.1177\/036354658000800411"],"URL":"https:\/\/doi.org\/10.1177\/036354658000800411","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,7]]}}}