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Within 24 hours following injection of IA, articular chon drocytes exhibited a marked loss in ability to synthesize PGs; this inhibition was complete after 2 weeks. Focal loss of SO staining of the interterritorial matrix was noted after 24 hours, progressing to a complete loss of staining after 2 weeks. In sharp contrast to the degenerative changes in the habitually loaded articular cartilage, cells at the chondrosynovial junction began incorporating Na\n                    <jats:sup>35<\/jats:sup>\n                    SO\n                    <jats:sub>4<\/jats:sub>\n                    and producing a matrix that stained with SO as early as 72 hours following injection. With time, this resulted in the development of prominent osteophytic cartilage that involved bone remodeling beneath the overlying cartilaginous cap after 3 weeks.\n                  <\/jats:p>","DOI":"10.1177\/036354658901700102","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T20:46:52Z","timestamp":1182458812000},"page":"7-15","source":"Crossref","is-referenced-by-count":16,"title":["Early osteophyte formation after chemically induced articular cartilage injury"],"prefix":"10.1177","volume":"17","author":[{"given":"James A.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Anatomy, Rush Medical College, Chicago, Illinois, Department of Internal Medicine, Rush Medical College, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene J.-M.A.","family":"Thonar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rush Medical College, Chicago, Illinois, Department of Biochemistry, Rush Medical College, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"atypb1","unstructured":"Barnett CH, Davies DV, MacConaill MA Synovial Joints Their Structure and Mechanics Springfield, IL, Charles C Thomas, 1961, pp 3-88"},{"key":"atypb2","unstructured":"Bennett GA Changes in the Knee Joint at Various Ages New York , The Commonwealth Fund, 1982"},{"key":"atypb3","unstructured":"Bennett GA, Bauer W.: Joint changes resulting from patellar displacement and their relation to degenerative joint disease J Bone Joint Surg 19: 667-682, 1937"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-25-290-76"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"Cassie GF, Dawson AS, Sheville E.: False aneurysm of femoral artery from cancellous exostosis of femur Report of a case in a boy of fourteen J Bone Joint Surg 57B. 379, 1975","DOI":"10.1302\/0301-620X.57B3.379"},{"key":"atypb6","unstructured":"Chrisman OD, Fessel JM, Southwick WO: Experimental production of synovitis and marginal articular exostoses in the knee joints of dogs. 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