{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:09:09Z","timestamp":1785474549105,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Sports Med"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>Restoring knee stability through reconstruction, while providing symptomatic relief, has not been shown to decrease the incidence of degenerative changes after rupture of the anterior cruciate ligament. This suggests that posttraumatic osteoarthritis may not be purely bio mechanical in origin, but also biochemical. To test this, we measured the levels of seven cytokine modulators of cartilage metabolism in knee joint synovial fluid after anterior cruciate ligament rupture. We also measured keratan sulfate, a product of articular cartilage catab olism. The sample population consisted of patients with uninjured knee joints ( N = 10), and patients with acute ( N = 60), subacute ( N = 18), and chronic ( N = 8) anterior cruciate ligament-deficient knees. Synovial fluid samples were analyzed by enzyme-linked immu nosorbent assays. Normal synovial fluids contained high levels of the interleukin-1 receptor antagonist but low concentrations of other cytokines. Immediately af ter ligament rupture there were large increases in in terleukins 6 and 8, tumor necrosis factor \u03b1, and keratan sulfate. Interleukin-1 levels remained low throughout the course. As the injury became subacute and then chronic, interleukin-6, tumor necrosis factor-\u03b1, and keratan sulfate levels fell but remained considerably elevated 3 months after injury. Concentrations of inter leukin-1Ra fell dramatically. Granulocyte-macrophage colony-stimulating factor concentrations were normal acutely and subacutely but by 3 months after injury were elevated 10-fold. Our data reveal a persistent and evolving disturbance in cytokine and keratan sulfate profiles within the anterior cruciate ligament-deficient knee, suggesting an important biochemical dimension to the development of osteoarthritis there.<\/jats:p>","DOI":"10.1177\/036354659702500605","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T20:46:52Z","timestamp":1182458812000},"page":"751-754","source":"Crossref","is-referenced-by-count":196,"title":["The Natural History of the Anterior Cruciate Ligament-Deficient Knee"],"prefix":"10.1177","volume":"25","author":[{"given":"Michelle","family":"Cameron","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Buchgraber","sequence":"additional","affiliation":[{"name":"University of Heidelberg School of Medicine, Zentrum f\u00fcr Sporttraumatologie und Gelenkchirurgie, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Passler","sequence":"additional","affiliation":[{"name":"University of Heidelberg School of Medicine, Zentrum f\u00fcr Sporttraumatologie und Gelenkchirurgie, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Thonar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rush Presbyterian School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60535-0"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(92)90192-E"},{"key":"atypb3","doi-asserted-by":"crossref","unstructured":"Barrack RL, Bruckner JD, Kneisl J., et al The outcome of nonoperatively treated complete tears of the anterior cruciate ligament in active young adults. 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Biology of disease Tumor necrosis factor and interleukin-1 Cytoknes with multiple overlapping biological activities Lab Invest 56 234-248, 1987"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321113"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062050-00002"},{"key":"atypb19","unstructured":"Morales TI The role of signaling factors in articular cartilage homeostasis and osteoarthritis , in Kuettner KE, Goldberg VM (eds) Osteoarthritic Disorders Rosemont, IL, AAOS, 1995, pp 261-270"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198401040-00004"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365020-00003"},{"key":"atypb22","unstructured":"Ongchi DR, Thonar EJ, Johnson C., et al Keratan sulfate content of synomal fluid after knee injury, in Kuettner KE, Schleyerbach R, Peyron JG, et al (eds) Articular Cartilage and Osteoarthritis New York, Raven Press, 1992, pp 734-735"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8749"},{"key":"atypb24","unstructured":"Poole AR Imbalances of anabolism and catabolism of cartilage matrix components in osteoarthritis , in Kuettner KE, Goldberg VM (eds) Osteoarthritic Disorders Rosemont, IL, AAOS, 1995, pp 247-260"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972788"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1038\/322547a0"}],"container-title":["The American Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/036354659702500605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/036354659702500605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:39:22Z","timestamp":1777369162000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/036354659702500605"}},"subtitle":["Changes in Synovial Fluid Cytokine and Keratan Sulfate Concentrations"],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1177\/036354659702500605"],"URL":"https:\/\/doi.org\/10.1177\/036354659702500605","relation":{},"ISSN":["0363-5465","1552-3365"],"issn-type":[{"value":"0363-5465","type":"print"},{"value":"1552-3365","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}