{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:21:05Z","timestamp":1791282065213,"version":"4.1.0"},"reference-count":69,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Food Nutr Bull"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The current magnitude of folate and vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      deficiency in Latin America and the Caribbean is uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To summarize data on plasma or serum vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      and folate concentrations in Latin America and the Caribbean reported since 1990, a period that covers the era before and after the introduction of folic acid fortification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic review was conducted in 2012 and updated in 2014. Studies and surveys using biochemical biomarkers and conducted in apparently healthy individuals were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Folate deficiency in Latin America and the Caribbean appears not to be a public health problem (prevalence &lt; 5%) after the introduction of folic acid fortification. However, there is some indication that high rates of low or marginal vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      status remain in most locations and across population groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Adding vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      as a fortificant with folic acid may be the best strategy in areas where vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      deficiency is an established concern.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0379572115585772","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T02:57:56Z","timestamp":1435201076000},"page":"S109-S118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["Folate and Vitamin B\n                    <sub>12<\/sub>\n                    Status in Latin America and the Caribbean"],"prefix":"10.1177","volume":"36","author":[{"given":"Alex","family":"Brito","sequence":"first","affiliation":[{"name":"US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Mujica-Coopman","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Olivares","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"L\u00f3pez de Roma\u00f1a","sequence":"additional","affiliation":[{"name":"Micronutrient Initiative, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Cori","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay H.","family":"Allen","sequence":"additional","affiliation":[{"name":"US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"bibr1-0379572115585772","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S103"},{"key":"bibr2-0379572115585772","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2003.1.62"},{"key":"bibr3-0379572115585772","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"bibr4-0379572115585772","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"bibr5-0379572115585772","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"bibr6-0379572115585772","unstructured":"Institute of Medicine. 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