{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:07:42Z","timestamp":1791929262329,"version":"4.3.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Food Nutr Bull"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A randomized controlled trial in Bangladeshi children aged 12 to 18 months with moderate acute malnutrition found that dietary supplementation with the microbiota-directed complementary food (MDCF-2) significantly improved weight gain and repaired gut microbiota compared to the ready-to-use supplementary food. However, the MDCF-2 formulation was made daily from locally available ingredients and the need for a packaged, nutritionally compliant, and organoleptically acceptable MDCF-2 prototype was essential for future large-scale clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The study aimed to develop and assess the acceptability of 3 alternative foil-packaged formulations of MDCF-2 in comparison to current MDCF-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Of the 3 packaged formulations, the Jumpstart version was provided in 2 sachets, the other 2 formulations were provided in a retort-stable foil pouch extended by sterilization, and microbiological growth was monitored over 10 months. The acceptability study included 40 children aged 8 to 12 months living in an urban slum in Dhaka, and the organoleptic properties were assessed using a 7-point hedonic scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the 100 g distributed over the 2 sessions, children consumed 82.5 \u00b1 7.84 g (mean \u00b1 SD) of kitchen-prepared MDCF-2, 85.4 \u00b1 7.15 g of the \u201cJumpstart\u201d MDCF-2 formulation, 85.4 \u00b1 8.70 g of the MDCF-2 with green banana powder, and 86.2 \u00b1\u20094.26 g of the MDCF-2 with sweet potato formulation. The \u201cJumpstart\u201d MDCF-2 and MDCF-2 with sweet potato achieved the highest overall acceptability scores on the hedonic scale; although none of the shelf-stable formulations were significantly different from the kitchen-prepared MDCF-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Packaged, shelf-stable prototypes of MDCF-2 exhibited comparable acceptability among Bangladeshi children aged 8 to 12 months to the original freshly prepared formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language title<\/jats:title>\n                    <jats:p>Development and Acceptability of Shelf-Stable Microbiota-Directed Complementary Foods<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03795721241250104","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T07:21:31Z","timestamp":1722324091000},"page":"67-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Development and Acceptability of Shelf-Stable Microbiota Directed Complementary Food Formulations"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-8245","authenticated-orcid":false,"given":"Ishita","family":"Mostafa","sequence":"first","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umme Habiba","family":"Lamiya","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Golam","family":"Rasul","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-6217","authenticated-orcid":false,"given":"Nurun Nahar","family":"Naila","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-202X","authenticated-orcid":false,"given":"Shah Mohammad","family":"Fahim","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-4072","authenticated-orcid":false,"given":"S. M. Tafsir","family":"Hasan","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Barratt","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"},{"name":"Office of the Executive Director, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"bibr1-03795721241250104","unstructured":"WHO, UNICEF, International Bank for Reconstruction and Development\/World Bank. Levels and trends in child malnutrition: UNICEF\/WHO\/World Bank Group Joint Child Malnutrition Estimates: key findings of the 2023 edition. UNICEF and WHO; 2023."},{"key":"bibr2-03795721241250104","unstructured":"World Health Organization. Supplementary foods for the management of moderate acute malnutrition in children aged 6-59 months. 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