{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:55:55Z","timestamp":1777784155248,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Different techniques of continuous renal replacement therapy (CRRT) might have different effects on electrolyte and acid-base control. The aim of this study was to determine whether continuous veno-venous hemodiafiltration (CVVHDF) or continuous veno-venous hemofiltration (CVVH) achieve better control of serum sodium, potassium and bicarbonate concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two tertiary intensive care units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Critically ill patients with acute renal failure (ARF) treated with CVVHDF (n=49) or CVVH (n=50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Retrieval of daily morning sodium and potassium values and arterial bicarbonate levels from computerized biochemical records before and after the initiation of CRRT for up to 2 weeks of treatment. Statistical comparison of findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and results<\/jats:title>\n                    <jats:p>Before treatment, abnormal (high or low) values were frequently observed for sodium (65.1% for CVVHDF vs. 80.0% for CVVH; NS), potassium (45.9% vs. 34.0%; NS), and bicarbonate (73.3% vs. 68.0%; NS). After treatment, however, CVVHDF was more likely to achieve serum sodium concentrations within the normal range (74.1% vs. 62.9%; p=0.0026). Both treatments decreased the mean serum potassium concentration over the first 48 h (p=0.0059 and p &lt;0.0001, respectively), but there was no difference in terms of the normalization of serum potassium concentration during the entire treatment period (88.3% vs. 90.5%; NS). Both treatments increased the mean arterial bicarbonate concentration over the first 48 hours (p=0.011 and p &lt;0.0001, respectively). However, CVVH was associated with a lower incidence of metabolic acidosis (13.8% for CVVH vs. 34.5% for CVVHDF; p &lt;0.0001) and a higher incidence of metabolic alkalosis (38.9% vs. 1.1%; p &lt;0.0001) during the entire treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRRT strategies based on different techniques have a significantly different impact on sodium and bicarbonate control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/039139880302600403","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T01:22:34Z","timestamp":1516324954000},"page":"289-296","source":"Crossref","is-referenced-by-count":22,"title":["Continuous Renal Replacement Therapy: Does Technique Influence Electrolyte and Bicarbonate Control?"],"prefix":"10.1177","volume":"26","author":[{"given":"H.","family":"Morimatsu","sequence":"first","affiliation":[{"name":"Department of Intensive Care and Department of Medicine, Austin & Repatriation Medical Centre, Melbourne, Victoria - Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Department of Medicine, Austin & Repatriation Medical Centre, Melbourne, Victoria - Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Department of Medicine, Austin & Repatriation Medical Centre, Melbourne, Victoria - Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ronco","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ospedale San Bortolo, Vicenza - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"bibr1-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199602000-00003"},{"key":"bibr2-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1159\/000168271"},{"key":"bibr3-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9907016"},{"key":"bibr4-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200110000-00010"},{"key":"bibr5-039139880302600403","first-page":"187","volume":"40","author":"Ronco C.","year":"1993","journal-title":"Clin Nephrol"},{"key":"bibr6-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9708602"},{"key":"bibr7-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1186\/cc718"},{"key":"bibr8-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.2.230"},{"key":"bibr9-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.318"},{"key":"bibr10-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027305"},{"key":"bibr11-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90084-0"},{"key":"bibr12-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100953"},{"key":"bibr13-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198510000-00009"},{"issue":"66","key":"bibr14-039139880302600403","first-page":"S151","volume":"53","author":"Locatelli F.","year":"1998","journal-title":"Kidney Int"},{"key":"bibr15-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.245"},{"key":"bibr16-039139880302600403","first-page":"89","volume":"17","author":"Swank S.K.","year":"1991","journal-title":"Miner Electrolyte Metab"},{"key":"bibr17-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005253422107"},{"key":"bibr18-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1159\/000424611"},{"key":"bibr19-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.56.s72.17.x"},{"key":"bibr20-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051052"},{"key":"bibr21-039139880302600403","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.6.1212"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880302600403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880302600403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:39:43Z","timestamp":1777491583000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/039139880302600403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1177\/039139880302600403"],"URL":"https:\/\/doi.org\/10.1177\/039139880302600403","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}