{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:04:38Z","timestamp":1791281078700,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate, quantify and compare the effects of continuous veno-venous hemofiltration (CVVH) with lactate or bicarbonate-buffered replacement fluids on acid-base balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized double crossover study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Intensive Care Unit of Tertiary Medical Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Eight patients with severe acute renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Random allocation to either 2 hours of isovolemic lactate-buffered (treatment A) CVVH or 2 hours of bicarbonate-buffered (treatment B) CVVH with cross over and with same procedure repeated the following day (double cross over).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Results<\/jats:title>\n                    <jats:p>\n                      Timed collections of arterial blood and ultrafiltrate (UF), measurement of blood and UF gases and lactate concentrations and calculation of buffer-base mass balance. At baseline, both groups of patients had a similar, slight metabolic alkalosis (pH: 7.45 vs. 7.45; BE 3.9 mEq\/L for treatment A and 4.0 for treatment B) and a serum bicarbonate of 28.1 mmol\/L for treatment A vs. 28.3 mmol\/L for treatment B; all NS. This alkalosis was present despite slight hyperlactatemia in both groups (A: 2.4 mmol\/L vs. B 2.8 mmol\/L; NS). Within 60 minutes of treatment, however, treatment A led to a significantly higher lactate concentration (3.9 vs 2.5 mmol\/L; p=0.0011), a significantly lower BE (2.3 vs 4.1 mEq\/L; p=0.0019) and a significantly lower bicarbonate concentration (26.7 vs. 28.3 mmol\/L; p=0.0038) in the presence of an unchanged PaCO\n                      <jats:sub>2<\/jats:sub>\n                      . These differences persisted during the study period. The UF of patients receiving treatment A contained more lactate (10.2 vs 2.9 mmol\/L; p&lt;0.0001) and less bicarbonate (25.6 vs. 30.8 mmol\/L; p&lt;0.0001) than treatment B resulting in a mean buffer-base balance of +20.4 mEq\/h compared to \u22122.6 mEq\/h for treatment B; p&lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CVVH with lactate-buffered replacement fluids induces iatrogenic hyperlactatemia. Such hyperlactatemia is associated with an acidifying effect despite a positive buffer-base balance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/039139880302600605","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T01:23:07Z","timestamp":1516324987000},"page":"477-483","source":"Crossref","is-referenced-by-count":25,"title":["The Acid-Base Effects of Continuous Hemofiltration with Lactate or Bicarbonate Buffered Replacement Fluids"],"prefix":"10.1177","volume":"26","author":[{"given":"H.K.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Intensive Care and Department of Surgery, Austin & Repatriation Medical Centre, Heidelberg, Victoria - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Department of Surgery, Austin & Repatriation Medical Centre, Heidelberg, Victoria - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Department of Surgery, Austin & Repatriation Medical Centre, Heidelberg, Victoria - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"bibr1-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051047"},{"key":"bibr2-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051052"},{"issue":"72","key":"bibr3-039139880302600605","first-page":"S537","volume":"56","author":"Heering P.","year":"1999","journal-title":"Kidney Int"},{"key":"bibr4-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1159\/000186609"},{"key":"bibr5-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.6.1212"},{"key":"bibr6-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91470-5"},{"key":"bibr7-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199701000-00013"},{"key":"bibr8-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"bibr9-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120013969"},{"key":"bibr10-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200008000-00041"},{"key":"bibr11-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1097\/00075198-199912000-00002"},{"key":"bibr12-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1139\/y83-207"},{"key":"bibr13-039139880302600605","first-page":"713","volume":"120","author":"Figge J.","year":"1992","journal-title":"J Lab Clin Med"},{"key":"bibr14-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1016\/0883-9441(93)90001-2"},{"key":"bibr15-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00006"},{"key":"bibr16-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050930"},{"key":"bibr17-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00019"},{"key":"bibr18-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1995.tb04346.x"},{"key":"bibr19-039139880302600605","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.7.1101"},{"key":"bibr20-039139880302600605","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.7.1186"},{"key":"bibr21-039139880302600605","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90075-X"},{"key":"bibr22-039139880302600605","doi-asserted-by":"publisher","DOI":"10.3109\/08860229709026270"},{"key":"bibr23-039139880302600605","first-page":"854","volume":"8","author":"Nimmo G.R.","year":"1993","journal-title":"Nephrol Dial Transplant"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880302600605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880302600605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:39:53Z","timestamp":1777491593000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/039139880302600605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1177\/039139880302600605"],"URL":"https:\/\/doi.org\/10.1177\/039139880302600605","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}