{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:56:43Z","timestamp":1777784203424,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>\n                    The efficiency of a new bioartificial liver (BAL) containing small tissue fragments in the treatment of acute hepatic failure induced by carbon tetrachloride in rats was evaluated. A day after injection (i.p.) of CCl\n                    <jats:sub>4<\/jats:sub>\n                    the animals were connected to a BAL containing liver fragments (fragment BAL) and a BAL containing no liver fragments (no-fragment BAL), and extracorporeal hemoperfusion was carried out for 4 h. The activities of alanine transaminase and lactate dehydrogenase as well as the concentrations of ammonia, glucose, urea, and amino acids in plasma were measured. A tendency to the stabilisation of ammonia, glucose, phenylalanine, tyrosine, and other amino acids was revealed at the end of hemoperfusion in poisoned rats connected to the fragment BAL. A statistically significant difference in survival between the animals connected to the fragment BAL and no-fragment BAL was found. The results obtained indicate that the bioreactor containing small liver fragments is effective in the treatment of acute hepatic failure in animals.\n                  <\/jats:p>","DOI":"10.1177\/039139880302600806","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T01:20:39Z","timestamp":1516324839000},"page":"735-742","source":"Crossref","is-referenced-by-count":5,"title":["A Novel Bioartificial Liver Containing Small Tissue Fragments: Efficiency in the Treatment of Acute Hepatic Failure Induced by Carbon Tetrachloride in Rats"],"prefix":"10.1177","volume":"26","author":[{"given":"V.","family":"Soloviev","sequence":"first","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino - Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.N.E.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases and Research, Cairo - Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Akatov","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino - 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