{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:27:20Z","timestamp":1778696840485,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of the study was to examine the effect of hemodiafiltration with endogenous reinfusion (HFR) compared to hemodialysis (HD) on 28 uremic patients with secondary hyperparathyroidism (2HPT) but positively selected for good and stable control of phosphatemia in order to evaluate the independent effects of dialysis treatments on bone turnover metabolism. Methods: The study was divided into 3 periods of observation: a) HD for three months; b) HFR for three months; c) HFR for a further 3 months. We analysed the trend of: whole PTH, 1\u201384 PTH, 7\u201384 PTH, alkaline phosphatase and its bone isoenzyme, total and ionised calcium, phosphatemia, dose of phosphate binder agents, \u03b22-microglobulin, CRP. All the variations found were evaluated through mean values \u00b1 SD, t-tests, multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed a deceleration in bone turnover characterized by a reduction of the total and bone alkaline phosphatase (IU\/mL) from 92.3 \u00b1 82.8 and 35.8 \u00b1 49.8 at the end of HD to 63.4 \u00b1 23.9 and 16.0 \u00b1 8.7 at the end of HFR, respectively, and 1\u201384 PTH from 317.5 \u00b1 264.6 pg\/mL at the end of HD to 287.5 \u00b1 258.9 pg\/mL at the end of the 3\n                      <jats:sup>rd<\/jats:sup>\n                      month of HFR. \u03b22-microglobulin was reduced from 32.9 \u00b1 16.1 mg\/L at the end of HD to 26.4 \u00b1 8.1 mg\/L already at the end of the first three months of HFR. CRP was reduced from 2.5 \u00b1 2.6 mg\/dL at the beginning of the study to 1.3 \u00b1 1.7 mg\/dL at the end of HFR. There were no differences with regard to: dialytic efficiency, nutritional status, calcemia, phosphatemia (maintained in the K-DOQI range for the entire duration of the study), also thanks to more careful use of phosphate chelating agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We are of the opinion that HFR - essentially thanks to the use of ultrapure endogenous infusate - induces a deceleration in bone turnover due to 2PHT. In addition, phosphate substraction in HFR is better compared to HD, thanks to the improvement of the anti-inflammatory conditions by removing the cytokines harmful to bone metabolism and excluding a priori the negative effects related to hyperphosphatemia. (Int J Artif Organs 2006; 29: 1042\u201352)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/039139880602901104","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T01:54:16Z","timestamp":1515722056000},"page":"1042-1052","source":"Crossref","is-referenced-by-count":9,"title":["Effect of On-Line Hemodiafiltration with Endogenous Reinfusion (HFR) on the Calcium-Phosphorus Metabolism: Medium-Term Effects"],"prefix":"10.1177","volume":"29","author":[{"given":"P.G.","family":"Bolasco","sequence":"first","affiliation":[{"name":"Territorial Nephrology and Dialysis Unit, Azienda USL n. 8, Cagliari - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Division, A.O. \u201cS. 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