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Elevated serum phosphate and calcium-phosphate product levels play an important role in the pathogenesis of secondary hyperparathyroidism and extra-skeletal calcification in dialysis patients. Furthermore, inorganic phosphate may cause vascular calcification directly through a real \u201cossification\u201d of the tunica media in the vasculature of ESRD patients.<\/jats:p>\n                  <jats:p>The \u201cclassical\u201d treatment of secondary hyperparathyroidism and hyperphosphatemia in ESRD patients consists of either calcium- or aluminum-based phosphate binders and calcitriol administration. Unfortunately, this \u201cold generation\u201d therapy is not free of complications. This review paper suggests that new calcium- and aluminum-free phosphate binders, such as lanthanum carbonate, can be used to treat hyperphosphatemia and secondary hyperparathyroidism in ESRD patients.<\/jats:p>","DOI":"10.1177\/039139880703000403","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T01:54:30Z","timestamp":1515722070000},"page":"293-300","source":"Crossref","is-referenced-by-count":11,"title":["Hyperphosphatemia in Dialysis Patients: The Therapeutic Role of Lanthanum Carbonate"],"prefix":"10.1177","volume":"30","author":[{"given":"M.","family":"Cozzolino","sequence":"first","affiliation":[{"name":"Renal Division, San Paolo Hospital, University of Milan, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Brancaccio","sequence":"additional","affiliation":[{"name":"Renal Division, San Paolo Hospital, University of Milan, Milan - 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