{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:55:02Z","timestamp":1777784102454,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives.<\/jats:title>\n                    <jats:p>Sepsis-induced thrombotic microangiopathy is successfully treated by plasma exchange therapy However, certain putative mediators of thrombotic microangiopathy may not be removed by plasma filtration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We conducted an in vitro study to determine whether plasma filtration can remove ultra-large von Willebrand factor (ULvWF) multimers and other mediators. In separate experiments, human umbilical venous endothelial cell (HUVEC) supernatant enriched with ULvWF or human whole blood was passed through a therapeutic plasma exchange (TPE 2000, PRISMA) filter and samples were taken for measurement of ULvWF, vWF ristocetin cofactor, vWF antigen and PAI-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The sieving coefficients for vWF and PAI-1 were above 0.9. The ULvWF was gradually eliminated, and nearly disappeared after four circulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>The TPE 2000 filter can directly remove potential mediators of sepsis-induced thrombotic microangiopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/039139880703000507","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T01:56:51Z","timestamp":1515722211000},"page":"401-406","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Filtration on Mediators of Thrombotic Microangiopathy: An in Vitro Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Z. Y.","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Hemapheresis and Blood Services, The Institute for Transfusion Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cortese-Hassett","sequence":"additional","affiliation":[{"name":"Hemapheresis and Blood Services, The Institute for Transfusion Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Carcillo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor School of Medicine, Houston, Texas - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Kellum","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"bibr1-039139880703000507","first-page":"1","volume":"34","author":"Kwan H.C.","year":"1997","journal-title":"Semin Hematol"},{"key":"bibr2-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200107000-00001"},{"key":"bibr3-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.04.004"},{"key":"bibr4-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.06.007"},{"key":"bibr5-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00017-6"},{"key":"bibr6-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250604"},{"key":"bibr7-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250605"},{"key":"bibr8-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1159\/000170250"},{"key":"bibr9-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1159\/000170251"},{"key":"bibr10-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1177\/039139880502800506"},{"key":"bibr11-039139880703000507","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10262"},{"key":"bibr12-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01360.x"},{"key":"bibr13-039139880703000507","doi-asserted-by":"crossref","first-page":"615","DOI":"10.47102\/annals-acadmedsg.V34N10p615","volume":"34","author":"Tan H.K.","year":"2005","journal-title":"Ann Acad Med Singapore"},{"key":"bibr14-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2111"},{"key":"bibr15-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1186\/cc5064"},{"key":"bibr16-039139880703000507","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70362-7"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880703000507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880703000507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:39:32Z","timestamp":1777491572000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/039139880703000507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1177\/039139880703000507"],"URL":"https:\/\/doi.org\/10.1177\/039139880703000507","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}