{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:01:07Z","timestamp":1787670067671,"version":"build-2736575974"},"reference-count":83,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Bichat first described the mesothelium in 1827 but despite its early discovery, it has only been in recent years that its importance both in health and disease has been realised. One area still poorly understood is that of the mechanisms regulating mesothelial repair. Mesothelial cells are derived from the mesoderm but express many epithelial characteristics. However, mesothelium does not heal in the same way as other epithelial-like cells. Epithelium heals by centripetal migration, with cells at the edge of the wound proliferating and migrating into the injured area. Hertzler in 1919 noted that both large and small peritoneal injuries healed within the same time frame, concluding that the mesothelium could not heal solely by centripetal migration. The exact mechanisms involved in mesothelial regeneration following injury are controversial with a number of proposals suggested to explain the origin of the regenerating cells. This review will examine these proposals and give some insights into the likely mechanisms involved.<\/jats:p>","DOI":"10.1177\/039139880703000606","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T01:54:56Z","timestamp":1515722096000},"page":"484-494","source":"Crossref","is-referenced-by-count":25,"title":["The Origin of Regenerating Mesothelium: A Historical Perspective"],"prefix":"10.1177","volume":"30","author":[{"given":"S.E.","family":"Mutsaers","sequence":"first","affiliation":[{"name":"Anatomical Pathology, PathWest Laboratory Medicine WA, Nedlands, WA - Australia"},{"name":"Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Nedlands, WA - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pr\u00eale","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, and Centre for Child Health Research, University of Western Australia, Nedlands, WA - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Lansley","sequence":"additional","affiliation":[{"name":"Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Nedlands, WA - Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.E.","family":"Herrick","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester - UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"bibr1-039139880703000606","unstructured":"HertzlerA.E. The Peritoneum. St Louis: CV Mosby Company, 1919; 264\u20135."},{"key":"bibr2-039139880703000606","unstructured":"BrunschwigA., RobbinsG.F. Regeneration of peritoneum: Experimental observations and clinical experience in radical resections of intra-abdominal cancer. In XV Cong Soc Int Chir, Lisbone, 1954. Henri De Smeldt, Bruxelles, 1954; pp 756\u201365."},{"key":"bibr3-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800520616"},{"key":"bibr4-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194909000-00014"},{"key":"bibr5-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004217409"},{"key":"bibr6-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800601214"},{"key":"bibr7-039139880703000606","first-page":"361","volume":"46","author":"Teranishi S.","year":"1977","journal-title":"Nippon Geka Hokan"},{"key":"bibr8-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700730102"},{"key":"bibr9-039139880703000606","first-page":"93","volume":"71","author":"Ryan G.B.","year":"1973","journal-title":"Am J Pathol"},{"key":"bibr10-039139880703000606","doi-asserted-by":"publisher","DOI":"10.3109\/01902148309061509"},{"key":"bibr11-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64888-2"},{"key":"bibr12-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711450204"},{"key":"bibr13-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1966.68.4.501"},{"issue":"7","key":"bibr14-039139880703000606","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1242\/jcs.115.7.1383","volume":"115","author":"Foley-Comer A.J.","year":"2002","journal-title":"J Cell Sci"},{"key":"bibr15-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004921819"},{"key":"bibr16-039139880703000606","first-page":"604","volume":"26","author":"Watters W.B.","year":"1972","journal-title":"Lab Invest"},{"key":"bibr17-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1966.68.3.355"},{"key":"bibr18-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198601000-00005"},{"key":"bibr19-039139880703000606","doi-asserted-by":"publisher","DOI":"10.3109\/01913128709048326"},{"key":"bibr20-039139880703000606","first-page":"237","volume":"115","author":"Raftery A.T.","year":"1973","journal-title":"J Anat"},{"key":"bibr21-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.197"},{"key":"bibr22-039139880703000606","first-page":"10","volume":"72","author":"Ivanova V.F.","year":"1977","journal-title":"Arkh Anat Gistol Embriol"},{"key":"bibr23-039139880703000606","first-page":"41","volume":"12","author":"Diment A.V.","year":"1970","journal-title":"Tsitologiia"},{"key":"bibr24-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510309"},{"key":"bibr25-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1007\/BF01935739"},{"key":"bibr26-039139880703000606","first-page":"24","volume":"72","author":"Mutsaers S.E.","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"bibr27-039139880703000606","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF02889296","volume":"13","author":"Watters W.B.","year":"1973","journal-title":"Virchows Arch B Cell Pathol"},{"key":"bibr28-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<86::AID-PATH493>3.0.CO;2-G"},{"key":"bibr29-039139880703000606","first-page":"2","volume":"97","author":"Baradi A.F.","year":"1974","journal-title":"Arch Pathol"},{"key":"bibr30-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00490-8"},{"key":"bibr31-039139880703000606","first-page":"15","volume":"25","author":"Mouriquand J.","year":"1977","journal-title":"Pathol Biol (Paris)"},{"key":"bibr32-039139880703000606","first-page":"487","volume":"22","author":"Singh G.","year":"1978","journal-title":"Acta Cytol"},{"key":"bibr33-039139880703000606","first-page":"339","volume":"32","author":"Fishman J.A.","year":"1975","journal-title":"Lab Invest"},{"key":"bibr34-039139880703000606","doi-asserted-by":"publisher","DOI":"10.3109\/10408448209041321"},{"key":"bibr35-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1966.68.4.481"},{"key":"bibr36-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700880212"},{"key":"bibr37-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800610804"},{"key":"bibr38-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600412"},{"key":"bibr39-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001050302"},{"key":"bibr40-039139880703000606","first-page":"1279","volume":"36","author":"Isoda K.","year":"1986","journal-title":"Acta Pathol Jpn"},{"key":"bibr41-039139880703000606","first-page":"345","volume":"143","author":"Mohr W.","year":"1971","journal-title":"Beitr Pathol"},{"key":"bibr42-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1177\/039139888901200802"},{"key":"bibr43-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1159\/000186283"},{"key":"bibr44-039139880703000606","first-page":"179","volume":"34","author":"Di Paolo N.","year":"1990","journal-title":"Clin Nephrol"},{"key":"bibr45-039139880703000606","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/089686080302300404","volume":"23","author":"Hekking L.H.","year":"2003","journal-title":"Perit Dial Int"},{"key":"bibr46-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.6.1420"},{"key":"bibr47-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.7-1069"},{"key":"bibr48-039139880703000606","first-page":"402","volume":"2","author":"Nagy J.A.","year":"1995","journal-title":"Gene Ther"},{"key":"bibr49-039139880703000606","first-page":"393","volume":"2","author":"Nagy J.A.","year":"1995","journal-title":"Gene Ther"},{"key":"bibr50-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00698.x"},{"key":"bibr51-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.2629"},{"key":"bibr52-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1080\/11024159950189780"},{"key":"bibr53-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.618"},{"key":"bibr54-039139880703000606","first-page":"375","volume":"115","author":"Raftery A.T.","year":"1973","journal-title":"J Anat"},{"key":"bibr55-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580109"},{"key":"bibr56-039139880703000606","first-page":"1159","volume":"112","author":"Armstrong G.R.","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"bibr57-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80529-X"},{"key":"bibr58-039139880703000606","first-page":"547","volume":"142","author":"Davila R.M.","year":"1993","journal-title":"Am J Pathol"},{"key":"bibr59-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711390309"},{"key":"bibr60-039139880703000606","first-page":"1335","volume":"127","author":"Kalomenidis I.","year":"2005","journal-title":"Chest"},{"key":"bibr61-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65406-5"},{"key":"bibr62-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1007\/BF01534600"},{"key":"bibr63-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00159-1"},{"key":"bibr64-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1177\/089686089901900306"},{"key":"bibr65-039139880703000606","first-page":"53","volume":"35","author":"Gruenwald P.","year":"1943","journal-title":"Arch Pathol"},{"key":"bibr66-039139880703000606","first-page":"437","volume":"20","author":"Castor C.W.","year":"1969","journal-title":"Lab Invest"},{"key":"bibr67-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.150"},{"key":"bibr68-039139880703000606","first-page":"69","volume":"29","author":"Thiollet J.","year":"1978","journal-title":"Biomedicine"},{"key":"bibr69-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/5.3.256"},{"key":"bibr70-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(88)90002-6"},{"issue":"4","key":"bibr71-039139880703000606","first-page":"L382","volume":"265","author":"Owens M.W.","year":"1993","journal-title":"Am J Physiol"},{"key":"bibr72-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.130.2.267"},{"key":"bibr73-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80354-4"},{"key":"bibr74-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.6.1823"},{"key":"bibr75-039139880703000606","volume-title":"The mesothelium of the rat and its response to injury [PhD].","author":"Whitaker D.","year":"1984"},{"key":"bibr76-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020809"},{"key":"bibr77-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00861.x"},{"key":"bibr78-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198505000-00006"},{"key":"bibr79-039139880703000606","first-page":"25","volume-title":"Malignant mesothelioma.","author":"Whitaker D.","year":"1992"},{"key":"bibr80-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.4.1424"},{"key":"bibr81-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-40-472-275"},{"key":"bibr82-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418847"},{"key":"bibr83-039139880703000606","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02465.x"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880703000606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880703000606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:39:35Z","timestamp":1777491575000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/039139880703000606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/039139880703000606"],"URL":"https:\/\/doi.org\/10.1177\/039139880703000606","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}