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One of the foremost objectives of continuous renal replacement therapy (CRRT) is the removal of excess fluid and blood solutes that are retained as a consequence of decreased or absent glomerular filtration. Because prescription of CRRT requires goals to be set with regard to the rate and extent of both solute and fluid removal, a thorough understanding of the mechanisms by which solute and fluid removal occurs during CRRT is necessary. The following provides an overview of solute and water transfer during CRRT and this information is placed in the appropriate clinical context with a discussion of recent clinical trials assessing the relationship between CRRT dose and patient survival. Moreover, the differences between solute removal in CRRT and other dialysis modalities, especially sustained low-efficiency dialysis (SLED) and extended daily dialysis (EDD), along with the potential clinical implications are discussed.<\/jats:p>","DOI":"10.1177\/039139880803100608","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T02:00:22Z","timestamp":1515722422000},"page":"525-534","source":"Crossref","is-referenced-by-count":23,"title":["Operational Characteristics of Continuous Renal Replacement Modalities Used for Critically Ill Patients with Acute Kidney Injury"],"prefix":"10.1177","volume":"31","author":[{"given":"Z.","family":"Huang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Widener University, Philadelphia, Pennsylvania - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Letteri","sequence":"additional","affiliation":[{"name":"Gambro, Lakewood, Colorado - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Gambro, Lakewood, Colorado - USA"},{"name":"Nephrology Division, Indiana University School of Medicine, Indianapolis, Indiana - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ronco","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, International Renal Research Institute Vicenza (IRRIV), Vicenza - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, University of Washington, Seattle, Washington - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"bibr1-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.07822.x"},{"key":"bibr2-039139880803100608","first-page":"355","volume":"85","author":"Colton C.K.","year":"1975","journal-title":"J Lab Clin Med"},{"key":"bibr3-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703000207"},{"key":"bibr4-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.317"},{"key":"bibr5-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1159\/000078894"},{"key":"bibr6-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.suppl_5.56"},{"key":"bibr7-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00784.x"},{"key":"bibr8-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-585-36947-1_4"},{"key":"bibr9-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.377"},{"key":"bibr10-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139x.2001.00011.x"},{"key":"bibr11-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1159\/000423355"},{"key":"bibr12-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02430-2"},{"key":"bibr13-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1111\/j.1492-7535.2004.80415.x"},{"key":"bibr14-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2003.07288.x"},{"key":"bibr15-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1053\/jcrc.2002.36757"},{"key":"bibr16-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001705"},{"key":"bibr17-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg055"},{"key":"bibr18-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70199-3"},{"key":"bibr19-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70076-4"},{"key":"bibr20-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1177\/039139880402700509"},{"key":"bibr21-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2003.07282.x"},{"key":"bibr22-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010877"},{"key":"bibr23-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8973"},{"key":"bibr24-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060002777.x"},{"key":"bibr25-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V103601"},{"key":"bibr26-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.10.021"},{"key":"bibr27-039139880803100608","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007111173"},{"key":"bibr28-039139880803100608","first-page":"359","author":"The VA\/NIH Acute Renal Failure Trial Network.","year":"2008","journal-title":"N Engl J Med"},{"key":"bibr29-039139880803100608","unstructured":"Faulhaber-WalterR., HaferC., JahrN., VahlbruchJ., HallerH., FliserD., KielsteinJ. 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