{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:03:53Z","timestamp":1777784633222,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>The advent of direct-acting antiviral agents promises to change the management of hepatitis C in patients with end-stage renal disease, a patient group where the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a \u2018real-world\u2019 group of patients with end-stage renal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a single-arm, multi-centre study in a cohort (n=30) of patients with advanced chronic kidney disease (mostly on dialysis) who underwent antiviral therapy with direct-acting antiviral agents. The primary end-point was sustained virologic response (serum hepatitis C virus RNA &lt; 15 mIU\/mL, 12 weeks after treatment ended). We collected data on on-treatment adverse events, serious adverse events and laboratory abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 23 (77%) and 7 (23%) patients underwent regular dialysis and had chronic kidney disease at pre-dialysis stage, respectively. Six regimens were adopted: elbasvir\/grazoprevir ( n\u2009=\u20096), ledipasvir\/sofosbuvir\u2009\u00b1\u2009ribavirin ( n\u2009=\u20094), PrOD regimens\u2009\u00b1\u2009ribavirin ( n\u2009=\u200910), simeprevir\u2009+\u2009daclatasvir ( n\u2009=\u20093), sofosbuvir\u2009+\u2009daclatasvir\u2009\u00b1\u2009ribavirin ( n\u2009=\u20093), sofosbuvir\u2009+\u2009ribavirin ( n\u2009=\u20094). The SVR12 rate was 90% (95% confidence interval, 74%; 96%). A total of 27 (90%) patients achieved SVR12; there were three virologic failures \u2013 two were non-responders and one had a viral breakthrough while on therapy. Adverse events occurred in 53% (16\/30) (95% confidence interval, 0.39; 0.73) of patients and were managed clinically without discontinuation of therapy or hospitalization. The most common adverse event was anaemia ( n\u2009=\u200912) that required blood transfusions in seven individuals; deterioration of kidney function occurred in one (14%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>All-oral, interferon-free therapy with direct-acting antiviral agents for chronic hepatitis C virus in advanced chronic kidney disease was effective and well tolerated in a \u2018real-life\u2019 clinical setting. Careful monitoring of haemoglobin and serum creatinine during therapy with direct-acting antiviral agents is suggested. Studies are under way to address whether sustained viral response translates into better survival in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398818763478","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T07:15:40Z","timestamp":1522134940000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["\u2018Real-life\u2019 experience with direct-acting antiviral agents for hepatitis C virus in end-stage renal disease"],"prefix":"10.1177","volume":"41","author":[{"given":"Rebeca","family":"Garc\u00eda-Agudo","sequence":"first","affiliation":[{"name":"Nephrology Department, La Mancha-Centro Hospital, Alcazar de San Juan, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Aoufi-Rabih","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, La Mancha-Centro Hospital, Alcazar de San Juan, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Salgueira-Lazo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Gonz\u00e1lez-Corvillo","sequence":"additional","affiliation":[{"name":"Nephrology Department, Virgen del Roc\u00edo University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Fabrizi","sequence":"additional","affiliation":[{"name":"Nephrology Division, Maggiore Hospital and IRCCS Foundation, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"bibr1-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23486"},{"key":"bibr2-0391398818763478","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.144319"},{"key":"bibr3-0391398818763478","first-page":"133","volume":"7","author":"Zahran A","year":"2014","journal-title":"Arab J Nephrol Transplant"},{"key":"bibr4-0391398818763478","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.132236"},{"key":"bibr5-0391398818763478","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.152555"},{"key":"bibr6-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0238-z"},{"key":"bibr7-0391398818763478","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07940716"},{"key":"bibr8-0391398818763478","first-page":"188","volume":"33","author":"Garcia-Agudo R","year":"2013","journal-title":"Nefrologia"},{"key":"bibr9-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000391"},{"key":"bibr10-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135476"},{"key":"bibr11-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12276"},{"key":"bibr12-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00349-9"},{"key":"bibr13-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.078"},{"key":"bibr14-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7400.1167"},{"key":"bibr15-0391398818763478","unstructured":"AASLD (American Association for the Study of Liver Diseases) and IDSA (Infectious Disease Society of America). HCV guidance: recommendations for testing, managing, and treating hepatitis C, http:\/\/hcvguidelines.org (accessed 21 September 2017)."},{"key":"bibr16-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"bibr17-0391398818763478","first-page":"293","volume":"12","author":"Wong R","year":"2016","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"bibr18-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-013-0169-5"},{"key":"bibr19-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01633.x"},{"key":"bibr20-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1159\/000355615"},{"key":"bibr21-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12664"},{"key":"bibr22-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.037"},{"key":"bibr23-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12708"},{"key":"bibr24-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.403"},{"key":"bibr25-0391398818763478","first-page":"S1","volume":"73","author":"Kidney Disease: Improving Global Outcomes (KDIGO)","year":"2008","journal-title":"Kidney Int"},{"key":"bibr26-0391398818763478","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2575"},{"key":"bibr27-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-017-0158-1"},{"key":"bibr28-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13102"},{"key":"bibr29-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.044"},{"key":"bibr30-0391398818763478","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2015.1078908"},{"key":"bibr31-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.004"},{"key":"bibr32-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13078"},{"key":"bibr33-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13025"},{"key":"bibr34-0391398818763478","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000613"},{"key":"bibr35-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0817-y"},{"key":"bibr36-0391398818763478","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704053"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398818763478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0391398818763478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398818763478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:41:24Z","timestamp":1777491684000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0391398818763478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/0391398818763478"],"URL":"https:\/\/doi.org\/10.1177\/0391398818763478","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,27]]}}}