{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:19:39Z","timestamp":1789172379543,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Autogenous arteriovenous fistula is the preferred vascular access for hemodialysis, but it has high rates of non-maturation and early failure due to vascular stenosis. Convincing evidence supports a key role of local hemodynamics in vascular remodeling, suggesting that unsteady and disturbed flow conditions may be related to stenosis formation in arteriovenous fistula. The purpose of our study was to explore the feasibility of coupling contrast-free magnetic resonance imaging and computational fluid dynamics in longitudinal studies to identify the role of local hemodynamic changes over time in inducing vessel wall remodeling in arteriovenous fistula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We acquired contrast-free magnetic resonance imaging of arm vasculature at 1\u2009week and 6\u2009weeks after arteriovenous fistula creation in a 72-year-old patient. We then generated three-dimensional models and evaluated lumen cross-sectional area of arteriovenous fistula limbs. We performed high-resolution computational fluid dynamics to evaluate changes in local hemodynamics over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our contrast-free magnetic resonance imaging protocol provided good quality images in a short scan duration. We observed a homogeneous dilatation in the proximal artery, while there was a more pronounced lumen dilatation in the venous outflow as compared to a limited dilatation in the juxta-anastomotic vein. Furthermore, we observed a slight stabilization of the flow pattern over time, suggesting that vascular outward remodeling accommodates the flow to a more helicoidally phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Coupling contrast-free magnetic resonance imaging and high-resolution computational fluid dynamics represents a promising approach to shed more light in the mechanisms of vascular remodeling and can be used for prospective clinical investigations aimed at identifying critical hemodynamic factors contributing to arteriovenous fistula failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398818784207","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T05:18:54Z","timestamp":1531372734000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Toward longitudinal studies of hemodynamically induced vessel wall remodeling"],"prefix":"10.1177","volume":"41","author":[{"given":"Michela","family":"Bozzetto","sequence":"first","affiliation":[{"name":"Department of Engineering and Applied Sciences, University of Bergamo, Dalmine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[{"name":"USC Radiologia Diagnostica per Immagini 1, ASST Papa Giovanni XXIII\u2014Universit\u00e1 Milano-Bicocca, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rota","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Ene-Iordache","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, IRCCS\u2014Istituto di Ricerche Farmacologiche \u201cMario Negri,\u201d Ranica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sironi","sequence":"additional","affiliation":[{"name":"USC Radiologia Diagnostica per Immagini 1, ASST Papa Giovanni XXIII\u2014Universit\u00e1 Milano-Bicocca, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, Bergamo, Italy"},{"name":"Department of Biomedical Engineering, IRCCS\u2014Istituto di Ricerche Farmacologiche \u201cMario Negri,\u201d Ranica, Italy"},{"name":"Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Department of Management, Information and Production Engineering, University of Bergamo, Dalmine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.029"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.10.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01690213"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.08.023"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02950707"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11251210"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00370107"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159963"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv131"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.12.019"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-017-0323-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02030216"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn708"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr342"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1525-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3182a14e79"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24542"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-008-0420-1"},{"key":"e_1_3_3_20_2","volume-title":"Level set methods and marching cubes methods: evolving interfaces in computational geometry, fluid mechanics, computer vision and materials science","author":"Sethian JA","year":"1999","unstructured":"Sethian JA. 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