{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:11:43Z","timestamp":1784146303860,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infections are rare but associated with very high mortality rates. We report the case of a 14-year-old patient with Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infection and Influenza B pneumonia requiring veno-arterial extra-corporeal membrane oxygenator for refractory shock. In the absence of response to conventional therapy, we have inserted a Cytosorb\u00ae cartridge within the extra-corporeal membrane oxygenator circuit. A spectacular decrease in vasopressor requirements followed. Since clindamycin, a key component of Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus treatment, might be removed by Cytosorb\u00ae hemoadsorption, we have performed serial plasma concentrations measurements of the drug. Based on these measurements, we were able to develop a pharmacokinetic model incorporating variable plasma clearance. Patient\u2019s exposure was estimated before, during and after Cytosorb\u00ae hemoadsorption. According to this model, Cytosorb\u00ae hemoadsorption did not seem to result in significant clindamycin removal. Cytosorb\u00ae hemoadsorption during Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infection appears safe and feasible and no adaptation of clindamycin dosage seems necessary<\/jats:p>","DOI":"10.1177\/0391398819831303","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T01:24:39Z","timestamp":1551403479000},"page":"258-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Clindamycin clearance during Cytosorb\n                    <sup>\u00ae<\/sup>\n                    hemoadsorption: A case report and pharmacokinetic study"],"prefix":"10.1177","volume":"42","author":[{"given":"Elettra Camille","family":"Poli","sequence":"first","affiliation":[{"name":"Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Simoni","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical pharmacology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Buclin","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical pharmacology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Longchamp","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 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