{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:41:04Z","timestamp":1778784064964,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical and Health and Technology Project of Zhejiang Province","award":["2016KYB336"],"award-info":[{"award-number":["2016KYB336"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To study the different concentrations of Triton X-100 and nuclease needed to remove cells from the tracheal matrix of rabbits and analyse their biocompatibility and cellular compatibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty tracheas were harvested from donor New Zealand rabbits. Thirty tracheas were randomly divided into five groups (n = 6 each). The tracheas in group A were untreated and served as a control group, and those in groups B, C, D and E were treated with different concentrations of Triton X-100 (1%, 2%, 3% and 4%), respectively. The tracheas of the five groups were assessed by histological observation, scanning electron microscopy and mechanical evaluation. The remaining 20 donor tracheas, which were divided into a control group and an optimally decellularized group, were used for xenogeneic transplantation and cell seeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Many epithelial cells and cartilage cells were observed in the tracheas of group A. There were fewer cartilage cells in the tracheas of groups C, D and E than in the tracheas of groups A and B under histological observation. In scanning electron microscopy, there were many ciliated epithelial cells in the tracheas of group A; in groups B and C, the ciliated epithelial cells disappeared, but the basement membrane was intact. The basement membranes were broken in the tracheas of groups D and E. Implanted decellularized tracheas showed good biocompatibility. Bone marrow mesenchymal stem cells grown in the decellularized tracheal matrix grew well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Decellularized tracheal matrix obtained from rabbits by 2% Triton X-100 may be suitable for the construction of tissue-engineered trachea because of its favourable morphological and biomechanical properties as well as its biocompatibility and cellular compatibly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398819847216","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T07:55:36Z","timestamp":1557734136000},"page":"500-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Biocompatibility and cellular compatibility of decellularized tracheal matrix derived from rabbits"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-3860","authenticated-orcid":false,"given":"Fangbiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Lishui Municipal Central Hospital, Lishui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Clinical College of Yangzhou University, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Lishui Municipal Central Hospital, Lishui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Lishui Municipal Central Hospital, Lishui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongcan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Clinical College of Yangzhou University, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-3281","authenticated-orcid":false,"given":"Shu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Henan Chest Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"bibr1-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.02.042"},{"key":"bibr2-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61310-4"},{"key":"bibr3-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.034"},{"key":"bibr4-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600987750"},{"key":"bibr5-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61598-6"},{"key":"bibr6-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.067"},{"key":"bibr7-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.03.016"},{"key":"bibr8-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280602"},{"key":"bibr9-0391398819847216","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088794"},{"issue":"19","key":"bibr10-0391398819847216","first-page":"3675","volume":"27","author":"Gilbert 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