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A 41-year-old woman with recurrent driveline infections of HeartMate-II had sternotomy and debridement that was complicated by right ventricular failure requiring veno-arterial extracorporeal membrane oxygenation. Patient was comatose and acute onset of bradycardia occurred without any change in blood pressure or respiration. Computed tomography of brain demonstrated an uncal herniation from diffuse cerebral edema. Acute onset of bradycardia in comatose patients may be the sole component of Cushing\u2019s triad in laminar flow circulatory support.<\/jats:p>","DOI":"10.1177\/0391398819893701","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T01:38:18Z","timestamp":1576805898000},"page":"401-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Incomplete Cushing\u2019s reflex in extracorporeal membrane oxygenation"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-0958","authenticated-orcid":false,"given":"Sung-Min","family":"Cho","sequence":"first","affiliation":[{"name":"Neurosciences Critical Care Division, Departments of Neurology, Anesthesiology, and Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M","family":"Dodd-o","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"bibr1-0391398819893701","volume-title":"Concerning a definite regulatory mechanism of the Vaso-motor centre which controls blood pressure during cerebral compression","author":"Cushing H.","year":"1901"},{"key":"bibr2-0391398819893701","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90435-9"},{"issue":"1","key":"bibr3-0391398819893701","first-page":"56","volume":"49","author":"Su CF","year":"2006","journal-title":"Chin J Physiol"},{"key":"bibr4-0391398819893701","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.08.013"},{"key":"bibr5-0391398819893701","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.5.648"},{"key":"bibr6-0391398819893701","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969873"},{"issue":"6","key":"bibr7-0391398819893701","first-page":"621","volume":"28","author":"Mori A","year":"1987","journal-title":"J Cardiovasc Surg"},{"key":"bibr8-0391398819893701","doi-asserted-by":"publisher","DOI":"10.1007\/BF02480057"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398819893701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0391398819893701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398819893701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:41:56Z","timestamp":1777491716000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0391398819893701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1177\/0391398819893701"],"URL":"https:\/\/doi.org\/10.1177\/0391398819893701","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,19]]}}}