{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:22:45Z","timestamp":1778707365463,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>\n                    Gastrointestinal bleeding (GIB) especially from arteriovenous malformations (AVM) remains one of the devastating complications following continuous-flow left ventricular device (CF-LVAD) implantation. Blockade of angiotensin II pathway using angiotensin-converting enzyme inhibitors (ACEI)\/angiotensin receptor blockers (ARB) was reported to mitigate the risk of GIB and AVM-related GIB by suppressing angiogenesis. We performed a systematic review and meta-analysis to evaluate the association between ACEI\/ARB treatment and GIB in CF-LVAD population. Comprehensive literature search was performed through December 2019. We included studies reporting risk of GIB and\/or AVM-related GIB events in LVAD patients who received ACEI\/ARB with those who did not. Data from each study were combined using the random-effects to calculate odd ratios and 95% confidence intervals. Three retrospective cohort studies were included in this meta-analysis involving 619 LVADs patients (467 patients receiving ACEI\/ARB). The use of ACEI\/ARB was statistically associated with decreased incidence of overall GIB (pooled OR 0.35, 95% CI 0.22\u20130.56, I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.0%, p\u2009&lt;\u20090.001). There was a non-significant trend toward lower risk for AVM-related GIB in patients who received ACEI\/ARB (pooled OR 0.46, 95% CI 0.19\u20131.07, I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200951%, p\u2009=\u20090.07). Larger studies with specific definitions of ACEI\/ARB use and GIB are warranted to accurately determine the potential non-hemodynamic benefits of ACEI\/ARB in CF-LVAD patients.\n                  <\/jats:p>","DOI":"10.1177\/0391398820951811","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:14:35Z","timestamp":1598408075000},"page":"215-220","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Angiotensin II antagonists and gastrointestinal bleeding in left ventricular assist devices: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-1837","authenticated-orcid":false,"given":"Veraprapas","family":"Kittipibul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Miami\/Jackson Memorial Hospital, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasawat","family":"Vutthikraivit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakrin","family":"Kewcharoen","sequence":"additional","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattara","family":"Rattanawong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pakpoom","family":"Tantrachoti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapaipan","family":"Putthapiban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"bibr1-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.003"},{"key":"bibr2-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000998"},{"issue":"8","key":"bibr3-0391398820951811","first-page":"849","volume":"30","author":"Demirozu ZT","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"bibr4-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240709"},{"key":"bibr5-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21706"},{"key":"bibr6-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6_suppl.585S"},{"key":"bibr7-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019692"},{"key":"bibr8-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.01.1298"},{"key":"bibr9-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"bibr10-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.051"},{"key":"bibr11-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.12.016"},{"key":"bibr12-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.12.018"},{"key":"bibr13-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.004899"},{"key":"bibr14-0391398820951811","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.02.004"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398820951811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0391398820951811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398820951811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:15Z","timestamp":1777491735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0391398820951811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1177\/0391398820951811"],"URL":"https:\/\/doi.org\/10.1177\/0391398820951811","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]}}}