{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:33:39Z","timestamp":1780565619547,"version":"3.54.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Venovenous extracorporeal membrane oxygenation (VV ECMO) has gained popularity for the treatment of refractory respiratory failure during and after the 2009 influenza pandemic, and still represents a precious therapeutic resource for severe novel coronavirus 2019 infection. However, most of the published studies are small case series, and only two randomized trials exist in literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Aim of this systematic review is to describe trends in VV ECMO treatment outcomes according to large studies only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched and included studies with more than 100 VV ECMO cases dated up to August 1st, 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-three studies published in the period 2011\u20132019 met inclusion criteria, for a total of 12,860 patients (age 46.3\u2009\u00b1\u200917.4\u2009years). ARDS was mainly by pneumonia, in 3126 (37%) cases; further 401(7%) patients had H1N1 Influenza A infection. Cannulation-related complications occurred in 502 (7%) cases. Weighted mean (95% confidence interval) of VV ECMO duration was 8.9 (8.7\u20139.1) days, and ICU stay was 23.6 (22.4\u201324.8) days. Mortality at the longest follow up available was 40%. Data collection in 70% of the studies had a duration of &gt;5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study reveals the characteristics of large case VV ECMO studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398820975408","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T15:10:49Z","timestamp":1606835449000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Venovenous ECMO treatment, outcomes, and complications in adults according to large case series: A systematic review"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-8399","authenticated-orcid":false,"given":"Jun Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pieri","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-5980","authenticated-orcid":false,"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mara","family":"Scandroglio","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Fominskiy","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, South 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